, Volume 91, Issue 2, pp 338-339
Date: 04 Feb 2010

Non-cirrhotic extrahepatic portal vein thrombosis: a 6-year long case history

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In the absence of liver cirrhosis or cancer, splanchnic vein thrombosis is rare. Additional risk factors are neoplasia, abdominal inflammatory disease, and inherited and acquired thrombophilia as reported in chronic myeloproliferative disorders (CMPD), i.e. polycythemia vera and essential thrombocythemia [1, 2]. The Janus kinase-2 somatic mutation (JAK2V617F) represents a risk factor for myeloproliferative diseases and is helpful in laboratory tests for the evaluation of unexplained abdominal vein thrombosis [35].

A 47-year-old man was referred (November 2007) to our gastroenterology unit for further investigations regarding complications related to portal hypertension. Extrahepatic portal vein thrombosis (EHPVT) was diagnosed in another Hospital 6 years before (November 2001) after the onset of acute abdominal pain. Basic investigations were performed in order to diagnose liver cirrhosis as the main cause of splanchnic vein thrombosis. Neither ascites nor encephalopathy was present at ...