Original Article

International Journal of Hematology

, Volume 91, Issue 2, pp 303-309

First online:

The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0

  • Ritsuro SuzukiAffiliated withDepartment of HSCT Data Management, Nagoya University School of Medicine Email author 
  • , Shigeki OhtakeAffiliated withThird Department of Internal Medicine, Kanazawa University School of Medicine
  • , Jin TakeuchiAffiliated withDepartment of Internal Medicine, Nihon University School of Medicine
  • , Masami NagaiAffiliated withFirst Department of Internal Medicine, Kagawa Medical University
  • , Yoshihisa KoderaAffiliated withDepartment of Internal Medicine, Japanese Red Cross Nagoya First Hospital
  • , Motohiro HamaguchiAffiliated withDepartment of Hematology, National Hospital Organization, Nagoya Medical Center
  • , Shuichi MiyawakiAffiliated withDepartment of Internal Medicine, Saiseikai Maebashi Hospital
  • , Takahiro KarasunoAffiliated withDepartment of Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • , Shigetaka ShimodairaAffiliated withDepartment of Internal Medicine, Japanese Red Cross Nagano Hospital
    • , Ryuzo OhnoAffiliated withAichi Cancer Center
    • , Shigeo NakamuraAffiliated withDepartment of Pathology, Nagoya University School of Medicine
    • , Tomoki NaoeAffiliated withDepartment of Hematology and Oncology, Nagoya University School of Medicine

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Immunological phenotyping of acute leukemia have provided enormous and important information for the classification and lineage determination of leukemia. Forty-nine patients with CD7+ CD56+ acute myeloid leukemia (AML) were analyzed. There were 17 patients of M0, which corresponded to myeloid/NK cell precursor acute leukemia, and 32 patients of AML other than M0 (9 each for M1 and M2, one for M3, 3 for M4, 4 for M5 and 6 for M7). Age distribution was similar between these two groups, but CD7+ CD56+ M0 showed significant male predominance than CD7+ CD56+ M1–M7 (M:F = 15:2 vs. 15:17, P = 0.006). The disease localization and the hematological manifestations were different, showing fewer white blood cell counts and circulating leukemic blasts, less anemia, less thrombocytopenia and more frequent extramedullary involvement in M0 group. The prognosis was poor in both groups, and there was no statistical difference. These findings suggest that extramedullary involvement of myeloid/NK cell precursor acute leukemia is not directly derived from the presence of CD7 and CD56 antigens on leukemic cells. The poor prognosis of CD7+ CD56+ M1–M7 suggests that this phenotype may act as a prognostic factor for AML, but this should be confirmed in further studies.


Acute myeloid leukemia Immunophenotyping CD7 CD56