International Journal of Hematology

, Volume 91, Issue 1, pp 136–139

A man with concomitant polycythaemia vera and chronic myeloid leukemia: the dynamics of the two disorders

Authors

    • Department of Medicine, Faculty of MedicineUniversity of Malaya
  • G. G. Gan
    • Department of Medicine, Faculty of MedicineUniversity of Malaya
  • V. S. Nadarajan
    • Department of Pathology, Faculty of MedicineUniversity of Malaya
  • N. A. Latiff
    • Department of Medicine, Faculty of MedicineUniversity of Malaya
  • N. Menaka
    • Department of Pathology, Faculty of MedicineUniversity of Malaya
Case Report

DOI: 10.1007/s12185-009-0471-6

Cite this article as:
Bee, P.C., Gan, G.G., Nadarajan, V.S. et al. Int J Hematol (2010) 91: 136. doi:10.1007/s12185-009-0471-6

Abstract

The co-occurrence of JAK2 V617F mutation with BCR-ABL reciprocal translocation is uncommon. We report a 60-year-old man who initially presented with phenotype of polycythemia vera (PV), which evolved into chronic myeloid leukemia and back to PV once treatment with imatinib was commenced. JAK2 V617F mutation and BCR-ABL fusion transcripts were detected in the initial sample. However, JAK2 V617F alleles diminished when BCR-ABL mRNA burden increased and reappeared once the patient was commenced on imatinib. The dynamic interaction between JAK2 V617F and BCR-ABL implies that two independent clones exist with the JAK2 V617F clone only achieving clonal dominance when BCR-ABL positive clones are suppressed by imatinib.

Keywords

Chronic myeloid leukemiaPolycythemia veraBcr-AblJAK2 V617F mutationStem cell

Copyright information

© The Japanese Society of Hematology 2010