, Volume 91, Issue 1, pp 149-151
Date: 18 Dec 2009

Salmonella enteritidis necrotising fasciitis in a multiple myeloma patient receiving bortezomib

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We report a case of a 65-year-old man with multiple myeloma being treated with bortezomib who suffered necrotising fasciitis (NF) due to Salmonella enteritidis.

The patient was admitted with a pathological fracture of the humerus in August 2006, which subsequently was found to be due to a plasmocytoma. Further investigation revealed an IgG kappa paraproteinaemia of 12.8 g/l with immune paresis, no Bence–Jones protein in the urine, but bone marrow trephine (BMT) showed 14% plasma cells. Skeletal survey showed no further bony abnormalities. Full blood count and renal function were normal. He was diagnosed with Salmon Durie stage 3 multiple myeloma. Only past medical history of note was hypertension. He received four cycles of vincristine, adriamycin and dexamethasone. However, his paraprotein started to increase on treatment; therefore, he received second-line treatment with cyclophosphamide, thalidomide and dexamethasone. His paraprotein decreased from 18 to 6 g/l. In December 2007, he u