International Journal of Hematology

, Volume 90, Issue 1, pp 1–5

Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: differential clinical importance of NPM1 mutation according to subtype

  • Youngil Koh
  • Juwon Park
  • Eun-Kyung Bae
  • Kwang-Sung Ahn
  • Inho Kim
  • Soo-Mee Bang
  • Jae-Hoon Lee
  • Sung-Soo Yoon
  • Dong Soon Lee
  • Young Yiul Lee
  • Seonyang Park
  • Byoung Kook Kim
Rapid Communication

DOI: 10.1007/s12185-009-0350-1

Cite this article as:
Koh, Y., Park, J., Bae, EK. et al. Int J Hematol (2009) 90: 1. doi:10.1007/s12185-009-0350-1

Abstract

Mutations of nucleophosmin gene (NPM1) are known to be related to good prognosis in AML patients lacking FLT3 internal tandem duplication (FLT3-ITD). Recently, NPM1 mutations other than type A were reported, but their clinical significance is not well known. Retrospective medical record review of 106 de novo AML patients lacking FLT3-ITD, who received induction chemotherapy from three centers in Korea between 1997 and 2007, was performed. Direct sequencing of NPM1 and RT-PCR for FLT3-ITD was performed on genomic DNA derived from blood samples of patients before induction chemotherapy for detection of mutations. NPM1 mutation was detected in 18 patients, where 13 were type A mutants and 5 were non-type A mutants. CR, CR1-D and OS was not different according to NPM1 mutational status overall. But, non-type A NPM1 mutation was related to shorter CR1-D when compared with NPM1 wild types and NPM1 type A mutation (p = 0.004). OS was shorter in non-type A mutants when compared with NPM1 wild-type patients and NPM1 type A mutants (p = 0.001). The type of mutation of NPM1 is important for prognosis in de novo AML lacking FLT3-ITD. Non-A type NPM1 mutation is a poor prognostic factor.

Keywords

AMLNPM1Prognosis

Copyright information

© The Japanese Society of Hematology 2009

Authors and Affiliations

  • Youngil Koh
    • 1
  • Juwon Park
    • 2
  • Eun-Kyung Bae
    • 3
  • Kwang-Sung Ahn
    • 2
  • Inho Kim
    • 1
    • 2
    • 4
  • Soo-Mee Bang
    • 5
  • Jae-Hoon Lee
    • 6
  • Sung-Soo Yoon
    • 1
    • 2
    • 4
  • Dong Soon Lee
    • 7
  • Young Yiul Lee
    • 8
  • Seonyang Park
    • 1
    • 2
    • 4
  • Byoung Kook Kim
    • 1
    • 2
    • 4
  1. 1.Department of Internal MedicineSeoul National University HospitalSeoulRepublic of Korea
  2. 2.Cancer Research InstituteSeoul National University College of MedicineSeoulRepublic of Korea
  3. 3.Department of Biomedical ScienceHanyang University College of MedicineSeoulRepublic of Korea
  4. 4.Clinical Research InstituteSeoul National University HospitalSeoulRepublic of Korea
  5. 5.Department of Internal MedicineSeoul National University Bundang HospitalSeongnamRepublic of Korea
  6. 6.Department of Internal MedicineGachon University College of Medicine Gil HospitalIncheonRepublic of Korea
  7. 7.Department of Clinical PathologySeoul National University HospitalSeoulRepublic of Korea
  8. 8.Department of Internal MedicineHanyang University HospitalSeoulRepublic of Korea