International Journal of Hematology

, Volume 89, Issue 5, pp 699–703

Therapy related CMML: a case report and review of the literature

  • Faheem Ahmed
  • Nadia Osman
  • Fred Lucas
  • Guy Neff
  • Teresa Smolarek
  • John M. Bennett
  • Rami S. Komrokji
Case Report

DOI: 10.1007/s12185-009-0318-1

Cite this article as:
Ahmed, F., Osman, N., Lucas, F. et al. Int J Hematol (2009) 89: 699. doi:10.1007/s12185-009-0318-1

Abstract

Therapy related chronic myelomonocytic leukemia (t-CMML) is rare. We report a 23-year-old female who developed acute fulminant hepatic failure after drug overdose. She underwent ABO incompatible orthotopic liver transplant. She received cyclophosphamide along with other immunosuppressants. Seven years later, she was diagnosed with t-CMML-2 with 45XX,-7 karyotype. She received 4 cycles of azacitidine and proceeded with allogeneic bone marrow transplant. This is the first a case of t-CMML reported in a liver transplant recipient. In this article, we also summarize all reported cases of t-CMML, and we review therapy related MDS in recipients of solid organ transplant.

Keywords

CMMLTherapy related MDSLiver transplantation

Copyright information

© The Japanese Society of Hematology 2009

Authors and Affiliations

  • Faheem Ahmed
    • 1
  • Nadia Osman
    • 1
  • Fred Lucas
    • 2
  • Guy Neff
    • 3
  • Teresa Smolarek
    • 4
  • John M. Bennett
    • 5
  • Rami S. Komrokji
    • 6
    • 7
  1. 1.Hematology and Medical Oncology Division, Department of Internal MedicineUniversity of CincinnatiCincinnatiUSA
  2. 2.Department of PathologyUniversity of CincinnatiCincinnatiUSA
  3. 3.Digestive Disease Division, Department of Internal MedicineUniversity of CincinnatiCincinnatiUSA
  4. 4.Division of Human Genetics, Department of Pediatrics, Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiUSA
  5. 5.Department of Medicine, The James P. Wilmot Cancer CenterUniversity of Rochester School of Medicine and DentistryRochesterUSA
  6. 6.Department of Oncologic SciencesUniversity of South FloridaTampaUSA
  7. 7.Department of Hematologic MalignanciesMoffitt Cancer Center and Research InstituteTampaUSA