International Journal of Hematology

, Volume 88, Issue 3, pp 299–303

Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation

  • Takashi Sonoki
  • Sonoko Ishihara
  • Shima Uneda
  • Nobuyoshi Hanaoka
  • Miwa Kurimoto
  • Hiroshi Matsuoka
  • Hideki Nakakuma
Case Report

DOI: 10.1007/s12185-008-0160-x

Cite this article as:
Sonoki, T., Ishihara, S., Uneda, S. et al. Int J Hematol (2008) 88: 299. doi:10.1007/s12185-008-0160-x

Abstract

We report a unique, aggressive B-cell lymphoma that developed after the long-term remission of follicular lymphoma (FL). FL cells were negative for CD5, whereas aggressive lymphoma cells were positive for CD5. In FL, one immunoglobulin heavy chain gene (IGH) allele underwent V/D/J recombination and another t(14;18)(q32;q21). In aggressive lymphoma, one IGH allele underwent D/J recombination and another translocation, but not t(14;18)(q32;q21). An aggressive lymphoma-specific D/J sequence was detected in FL tissue. Our results indicated that the two tumors arose from distinct B cells and that they existed concurrently in the same lymph node.

Keywords

Secondary lymphoma Follicular lymphoma CD5 t(14;18)(q32;q21) Immunoglobulin heavy chain gene 

Copyright information

© The Japanese Society of Hematology 2008

Authors and Affiliations

  • Takashi Sonoki
    • 1
  • Sonoko Ishihara
    • 2
  • Shima Uneda
    • 1
  • Nobuyoshi Hanaoka
    • 1
  • Miwa Kurimoto
    • 1
  • Hiroshi Matsuoka
    • 1
  • Hideki Nakakuma
    • 1
  1. 1.Department of Hematology/OncologyWakayama Medical UniversityWakayamaJapan
  2. 2.Department of Surgical PathologyKumamoto University School of MedicineKumamotoJapan