Case Report

International Journal of Hematology

, Volume 87, Issue 5, pp 527-531

First online:

Leukemic transformation of Langerhans cell sarcoma

  • Kousuke SumidaAffiliated withDepartment of Hematology, Saga Prefectural Hospital Koseikan
  • , Yuya YoshidomiAffiliated withDepartment of Hematology, Saga Prefectural Hospital Koseikan
  • , Hiroko KogaAffiliated withDepartment of Hematology, Saga Prefectural Hospital Koseikan
  • , Nobuo KuwaharaAffiliated withDepartment of Hematology, Saga Prefectural Hospital Koseikan
  • , Eijo MatsuishiAffiliated withDepartment of Hematology, Saga Prefectural Hospital Koseikan
  • , Kennosuke KarubeAffiliated withDepartment of Pathology, Kurume University School of Medicine
  • , Koichi OshimaAffiliated withDepartment of Pathology, Kurume University School of Medicine
  • , Hisashi GondoAffiliated withDepartment of Hematology, Saga Prefectural Hospital Koseikan Email author 

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Abstract

A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despite intensive chemotherapy, he died of disease progression 7 months after the initial diagnosis. Tumor cells in the leukemic phase expressed CD5, CD7, CD13, CD33, CD34, CD68, and CD123. These findings suggested leukemic transformation from Langerhans cell sarcoma. Leukemic transformation may be a clinical manifestation of advanced Langerhans cell sarcoma, and should be differentiated from acute myelogenous leukemia.

Keywords

Langerhans cell sarcoma Leukemic transformation Acute myelogenous leukemia