International Journal of Hematology

, Volume 87, Issue 5, pp 527–531

Leukemic transformation of Langerhans cell sarcoma

  • Kousuke Sumida
  • Yuya Yoshidomi
  • Hiroko Koga
  • Nobuo Kuwahara
  • Eijo Matsuishi
  • Kennosuke Karube
  • Koichi Oshima
  • Hisashi Gondo
Case Report

DOI: 10.1007/s12185-008-0063-x

Cite this article as:
Sumida, K., Yoshidomi, Y., Koga, H. et al. Int J Hematol (2008) 87: 527. doi:10.1007/s12185-008-0063-x

Abstract

A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despite intensive chemotherapy, he died of disease progression 7 months after the initial diagnosis. Tumor cells in the leukemic phase expressed CD5, CD7, CD13, CD33, CD34, CD68, and CD123. These findings suggested leukemic transformation from Langerhans cell sarcoma. Leukemic transformation may be a clinical manifestation of advanced Langerhans cell sarcoma, and should be differentiated from acute myelogenous leukemia.

Keywords

Langerhans cell sarcomaLeukemic transformationAcute myelogenous leukemia

Copyright information

© The Japanese Society of Hematology 2008

Authors and Affiliations

  • Kousuke Sumida
    • 1
  • Yuya Yoshidomi
    • 1
  • Hiroko Koga
    • 1
  • Nobuo Kuwahara
    • 1
  • Eijo Matsuishi
    • 1
  • Kennosuke Karube
    • 2
  • Koichi Oshima
    • 2
  • Hisashi Gondo
    • 1
  1. 1.Department of HematologySaga Prefectural Hospital KoseikanSagaJapan
  2. 2.Department of PathologyKurume University School of MedicineKurumeJapan