Knee osteoarthritis in women
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Osteoarthritis is a disease that progresses over time and culminates in the destruction of articular cartilage and joints. Thus, with an increasing elderly population the treatment of knee osteoarthritis has become a major healthcare issue. It has been shown that women are more severely impacted by knee osteoarthritis. Differences in knee anatomy, kinematics, previous knee injury, and hormonal influences may play a role. Sex difference with respect to osteoarthritis presentation, treatment, and the allocation of resources also exists. In general, women present for treatment in more advanced stages of osteoarthritis and have more debilitating pain than their male counterparts. In addition, healthcare providers are more likely to recommend total joint arthroplasty for their male patients. Understanding how and why these gender differences occur is instrumental in formulating an inclusive strategy for combating osteoarthritis in the future.
- Borkhoff CM, Hawker GA, Kreder HJ, Glazier RH, Mahomed NN, Wright JG. The effect of patient’s sex on physician’s recommendations for total knee arthroplasty. CMAJ. 2008;178:681–7.
- Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in elderly adults: a systematic review and meta-analysis. Osteoarthr Cartil. 2010;18:24–33. CrossRef
- Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987;30:914–8. CrossRef
- Felson DT, Zhang Y, Hannan MT, Naimack A, Weissman BN, Aliabadi P, et al. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1995;38:1500–5. CrossRef
- O’Connor MI. Osteoarthritis of the hip and knee: sex and gender differences. Orthop Clin N Am. 2006;37:559–68. CrossRef
- Srikanth VK, Fryer B, Math JL, Zhai G, Winzenberg TM, Hosmer D, et al. A meta-analysis of sex differences prevalence, incidence, and severity of osteoarthritis. Osteoarthr Cartil. 2005;13:769–81. CrossRef
- • Hanna FS, Teichtahl AJ, Wluka AE, Wang Y, Urquhart DM, English DR, et al. Women have increased rates of cartilage loss and progression of cartilage defects at the knee than men: a gender study of adults without clinical knee osteoarthritis. Menopause. 2009;4:666–70. In this study MRI imaging is used to assess and compare the difference in articular cartilage volume loss between men and women. Women demonstrated a greater overall average cartilage volume loss compared with men. CrossRef
- McAlindon TE, Cooper C, Kirwan JR, Dieppe PA. Knee pain and disability in the community. Br J Rheumatol. 1992;31:189–92. CrossRef
- O’Connor MI. Sex differences in osteoarthritis of the hip and knee. J Am Acad Orthop Surg. 2007;15:S23–5.
- McAlindon TE, Snow S, Cooper C, Dieppe PA. Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. Ann Rheum Dis. 1992;51:844–9. CrossRef
- Debi R, Mor A, Segal O, Segal G, Debbi E, Agar G, et al. Differences in gait patterns, function, and quality of life between males and females with knee osteoarthritis: a clinical trial. BMC Musculoskelet Disord. 2009;10:127–37. CrossRef
- O’Connor MI, Hooten EG. Gender disparities in knee osteoarthritis and TKA. Clin Orthop Relat Res. 2011;469:1883–5. CrossRef
- Thomas SG, Pagura SM, Kenney D. Physical activity and its relationship to physical performance in patients with end stage knee osteoarthritis. J Orthop Sports Phys Ther. 2003;12:745–54.
- Conley S, Rosenberg A, Crowninshield R. The female knee: anatomic variations. J Am Acad Orthop Surg. 2007;15:S31–6.
- Chapell JD, Yu B, Kirkendall DT, Garret WE. A comparison of knee kinetics between male and female recreational athletes in stop-jump tasks. Am J Sports Med. 2002;30:261–7.
- Ford KR, Myer GD, Hewett TE. Valgus knee motion during landing in high school female and male basketball players. Med Sci Sports Exerc. 2003;35:1745–50. CrossRef
- Ford KR, Myer GD, Toms HE, Hewett TE. Gender differences in kinematics of unanticipated cutting in young athletes. Med Sci Sports Exerc. 2005;37:124–9. CrossRef
- Kernozek TW, Torry MR, Van Hoof H, Cowley H, Tanner S. Gender differences in frontal and sagittal plane biomechanics during drop landings. Med Sci Sports Exerc. 2005;37:1003–12.
- Mendiquichia J, Ford KR, Quatman CE, Alentorn-Geil E, Hewett TE. Sex differences in proximal control of the knee joint. Sports Med. 2011;41:541–57. CrossRef
- Friel NA, Chu CR. The role of ACL injury in the development of posttraumatic knee osteoarthritis. Clin Sports Med. 2013;32:1–12. CrossRef
- Nelson F, Billinghurst RC, Pidoux I, Reiner A, Langworthy M, McDermott M, et al. Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament. Osteoarthr Cartil. 2006;2:114–9. CrossRef
- Chu CR, Beynnon BD, Dragoo JL, Fleisig GS, Hart JM, Khazzam M, et al. The EARTH group: the feasibility of randomized controlled trials for early arthritis therapies (EARTH) involving acute anterior cruciate ligament tear cohorts. Am J Sports Med. 2012;40:2648–52. CrossRef
- Richmond RS, Carlson CS, Register TC, Shanker G, Loeser RF. Functional estrogen receptors in adult articular cartilage: estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2. Arthritis Rheum. 2000;43:2081–90. CrossRef
- Zhang Y, McAlindon TE, Hannan MT, Chaisson CE, Klein R, Wilson PW, et al. Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham study. Arthritis Rheum. 1998;41:1867–73. CrossRef
- Pagura SM, Thomas SG, Woodhouse LJ, Ezzat S. Women awaiting knee replacement have reduced function and growth hormone. Clin Orthop Relat Res. 2003;415:202–13.
- Cho HJ, Chang CB, Yoo JH, Kim SJ, Kim TK. Gender difference in the correlation between symptom and radiographic severity in patients with knee osteoarthritis. Clin Orthop Relat Res. 2010;468:1749–58. CrossRef
- Katz JN, Wright EA, Guadagnoli E, Liang MH, Karlson EW, Cleary PD. Differences between men and women undergoing major orthopedic surgery for degenerative arthritis. Arthritis Rheum. 1994;37(5):687–94.
- MacDonald SJ, Charron KD, Bourne RB, Naudie DD, McCalden RW, Rorabeck CH. Gender — specific total knee replacement: prospectively collected clinical outcomes. Clin Orthop Relat Res. 2008;466:2612–6. CrossRef
- Suarez-Almazor ME, Souchek J, Kelly PA, O’Malley K, Byrne M, Richardson M, et al. Ethnic variation in knee replacement: patient preferences or uniformed disparity? Arch Intern Med. 2005;165:1117–24. CrossRef
- Feeley BT, Gallo RA, Sherman S, Williams RJ. Management of osteoarthritis of the knee in the active patient. J Am Acad Orthop Surg. 2010;18:407–16.
- Richmond J, Hunter D, Irrgang J, Jones MH, Levy B, Marx R, et al. Treatment of osteoarthritis of the knee (nonarthoplasty). J Am Acad Orthop Surg. 2009;17:591–600.
- van Baar ME, Dekker J, Oostendorp RA, Bijl D, Voorn TB, Billsma JW. Effectiveness of exercise in patients with osteoarthritis of hip or knee: 9 months follow up. Ann Rheum Dis. 2001;60:1123–30. CrossRef
- Jackson DW, Evans NA, Thomas BM. Accuracy of needle placement into the intra-articular space of the knee. J Bone Joint Surg Am. 2001;84-A:1522–7.
- McGary JG, Daruwalla ZJ. The efficacy, accuracy, and complications of corticosteroid injections of the knee joint. Knee Surg Sports Traumatol Arthrosc. 2011;19:1649–54. CrossRef
- Dragoo JL, Braun HJ, Kim HJ, Pham HD, Golish SR. The in vitro chondrotoxicity of single-dose local anesthetics. Am J Sports Med. 2012;4:794–9. CrossRef
- Dragoo JL, Korotkova T, Kim HJ, Jaqadish A. Chondrotoxicity of low pH, epinephrine, and preservatives found in local anesthetics containing epinephrine. Am J Sports Med. 2010;6:1154–9. CrossRef
- Watterson JR, Esdaile JM. Viscosupplementation: therapeutic mechanisms and clinical potential in osteoarthritis of the knee. J Am Acad Orthop Surg. 2000;8:277–84.
- • Jawahar R, Yang S, Eaton CB, McAlindon T, Lapane K. Gender-specific correlates of complementary and alternative medicine use for knee osteoarthritis. J Womens Health. 2012;21:1091–9. In this study the usage of CAM modalities are examined and compared between genders. Women were more likely than men to use CAM alone or in conjunction with conventional medications. CrossRef
- Kirkley A, Birmingham TB, Litchfield RB, Giffin JR, Willits KR, Wong CJ, et al. A randomized trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2008;359:1097–107. CrossRef
- Kurtz S, Ong K, Lau E, Ong K, Zhao K, Kelly M, et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg. 2007;4:780–5. CrossRef
- Hawker GA, Wright JG, Coyte PC, Williams JI, Harvey B, Glazer R, et al. Differences between men and women in the rate of use of hip and knee arthroplasty. N Engl J Med. 2000;342:1016–22. CrossRef
- •• Novicoff WM, Saleh KJ. Examining sex and gender disparities in total joint arthroplasty. Clin Orthop Relat Res. 2011;469:1824–8. In this study the utilization of total joint arthroplasty and the potential causes of disparities and between genders are examined and explained. Differences in physician related and patient related issues are discussed. CrossRef
- O’Connor MI. Implant survival, knee function, and pain relief after TKA: are there differences between men and women? Clin Orthop Relat Res. 2011;469:1846–51. CrossRef
- Ritter MA, Wing JT, Berend ME, Davis KE, Meding JB. The clinical effect of gender on outcome of total knee arthroplasty. J Arthroplasty. 2008;23:331–6. CrossRef
- Petterson SC, Raisis L, Bodenstab A, Snyder-Makler L. Disease-specific gender differences among total knee arthroplasty candidates. J Bone Joint Surg Am. 2007;89:2327–33. CrossRef
- Boyan BD, Tosi L, Coutts R, et al. On the horizon from the ORS. J Am Acad Orthop Surg. 2012;20:668–9. CrossRef
- Dalury DF, Mason JB, Murphy JA, Adams MJ. Analysis of the outcome in male and female patients using a unisex total knee replacement system. J Bone Joint Surg Br. 2009;91:357–60. CrossRef
- Fortin PR, Clarke AE, Joseph L, Liang MH, Tanzer M, Ferland D, et al. Outcomes of total hip and knee replacement: preoperative functional status predicts outcome at 6 months after surgery. Arthritis Rheum. 1999;42:1722–8. CrossRef
- Chang HJ, Mehta PS, Rosenberg A, Scrimshaw SC. Concerns of patients actively contemplating total knee replacement: differences by race and gender. Arthritis Rheum. 2004;51:117–23. CrossRef
- Karlson EW, Daltroy LH, Liang MH, Eaton HE, Katz JN. Gender differences in patient preferences may underlie differential utilization of elective surgery. Am J Med. 1997;102:524–30. CrossRef
- Ramasubbu K, Gurm H, Litaker D. Gender bias in clinical trials: do double standards still apply? J Womens Health Gend Based Med. 2001;10:757–64. CrossRef
- Simon V. Wanted: women in clinic trials. Science. 2005;308:1517. CrossRef
- Knee osteoarthritis in women
Current Reviews in Musculoskeletal Medicine
Volume 6, Issue 2 , pp 182-187
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