Date: 19 Jun 2014

Preventing Heart Failure in Inflammatory and Immune Disorders

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Patients with chronic inflammatory diseases are at increased risk of heart failure due to ischemic heart disease and other causes including heart failure with preserved ejection fraction. Using rheumatoid arthritis and treated HIV infection as two prototypical examples, we review the epidemiology of heart failure in these populations and potential therapies to prevent it. Particular focus is given to antiinflammatory therapies including statins and biologic disease-modifying drugs. There is also limited evidence for lifestyle changes and blockade of the renin-angiotensin-aldosterone system. We conclude by proposing how a strategy for heart failure prevention, such as the model tested in the Screening To Prevent Heart Failure (STOP-HF) trial, may be adapted to chronic inflammatory disease.