Preventing Heart Failure in Inflammatory and Immune Disorders

Heart Failure Prevention (W Tang, Section Editor)

DOI: 10.1007/s12170-014-0392-7

Cite this article as:
Serhal, M. & Longenecker, C.T. Curr Cardiovasc Risk Rep (2014) 8: 392. doi:10.1007/s12170-014-0392-7
Part of the following topical collections:
  1. Topical Collection on Heart Failure Prevention


Patients with chronic inflammatory diseases are at increased risk of heart failure due to ischemic heart disease and other causes including heart failure with preserved ejection fraction. Using rheumatoid arthritis and treated HIV infection as two prototypical examples, we review the epidemiology of heart failure in these populations and potential therapies to prevent it. Particular focus is given to antiinflammatory therapies including statins and biologic disease-modifying drugs. There is also limited evidence for lifestyle changes and blockade of the renin-angiotensin-aldosterone system. We conclude by proposing how a strategy for heart failure prevention, such as the model tested in the Screening To Prevent Heart Failure (STOP-HF) trial, may be adapted to chronic inflammatory disease.


Heart failure HIV Rheumatoid arthritis Inflammation 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.University Hospitals Case Medical CenterClevelandUSA
  2. 2.Case Western Reserve University School of MedicineUniversity Hospitals Harrington Heart & Vascular InstituteClevelandUSA

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