Current Cardiovascular Risk Reports

, 8:379

Review Article: An Adipocentric View of the Metabolic Syndrome and Cardiovascular Disease

Authors

  • Michael Conall Dennedy
    • Department of Clinical BiochemistryUniversity of Cambridge Metabolic Research Laboratories, Level 4, MRC / Wellcome Trust Institute of Metabolic Science
    • National University of Ireland & Galway University Hospitalc/o Discipline of Clinical Pharmacology & Therapeutics, Clinical Sciences Institute, National University of Ireland, Galway
    • Department of Clinical BiochemistryUniversity of Cambridge Metabolic Research Laboratories, Level 4, MRC / Wellcome Trust Institute of Metabolic Science
    • Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton
Lipids (J Ordovas, L Parnell, Section Editors)

DOI: 10.1007/s12170-014-0379-4

Cite this article as:
Dennedy, M.C. & Vidal-Puig, A. Curr Cardiovasc Risk Rep (2014) 8: 379. doi:10.1007/s12170-014-0379-4
Part of the following topical collections:
  1. Topical Collection on Lipids

Abstract

Dysfunctional adipose tissue impairs whole body lipid buffering, influencing the storage of lipids as well as their use as an energy source. Ectopic deposition of lipids within metabolic tissues arises as a result of adipose tissue dysfunction and the ensuing systemic lipotoxicity explains much of the pathogenesis underlying insulin resistance and cardiometabolic disease. Adipose tissue dysfunction appears to be a multifactorial, maladaptive response to a lipid-rich, high calorie diet which involves the interplay between adipocyte precursors, adipocytes, immune cells, lipoprotein carriers and metabolically active tissues. Understanding these interactions and unravelling the adipocentric nature of cardiometabolic complications relating to obesity is a major priority towards addressing the worldwide obesity pandemic and its costly complications.

Keywords

LipotoxicityMetabolic SyndromeObesityAdipose TissueCardiovascular

Copyright information

© Springer Science+Business Media New York 2014