Current Cardiovascular Risk Reports

, Volume 7, Issue 1, pp 9–16

Resveratrol: Effects on Lipids and Cardiovascular Risk

Lipids (J Ordovas, Section Editor)

DOI: 10.1007/s12170-012-0289-2

Cite this article as:
Cherniack, E.P. & Troen, B.R. Curr Cardiovasc Risk Rep (2013) 7: 9. doi:10.1007/s12170-012-0289-2

Abstract

For several decades, there has been increasing interest in the possible use of resveratrol as a preventative agent in cardiovascular disease. Resveratrol exerts numerous effects on adipocyte, hepatocyte, and endothelial cell development and function. Many investigations have demonstrated the ability of resveratrol to regulate the adipocyte lifecycle, lipid synthesis, and improve hepatic lipid metabolism. Resveratrol has numerous vascular protective effects on endothelial tissue, including its antiplatelet activity. Resveratrol also reduces intracellular oxidative stress. Animal models of obesity and cardiovascular diseases have yielded important contributions to our understanding of the effects of resveratrol on the vasculature and the risk for pathology. In limited human studies, resveratrol reduces the release of proinflammatory cytokines and improves systemic glucose and insulin regulation and decreases cellular oxidative stress. Therefore, resveratrol has significant potential as both a prophylactic and treatment agent. However additional studies are required to more completely characterize its impacts on human physiology and its benefits in the setting of disease.

Keywords

Resveratrol Cardiovascular disease Lipids Adipocytes Oxidative stress Inflammation 

Copyright information

© Springer Science+Business Media New York (outside the USA) 2012

Authors and Affiliations

  1. 1.Division of Gerontology and Geriatric MedicineUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Geriatric Research Education and Clinical Center and Research ServiceBruce W. Carter Veterans Administration Medical CenterMiamiUSA