Current Cardiovascular Risk Reports

, Volume 6, Issue 5, pp 380–396

Cognition and Hemodynamics

Elderly and Cardiovascular Disease (DE Forman and JM Gaziano, Section Editors)

DOI: 10.1007/s12170-012-0260-2

Cite this article as:
Novak, V. Curr Cardiovasc Risk Rep (2012) 6: 380. doi:10.1007/s12170-012-0260-2


The relationship between cerebral hemodynamics and cognitive performance has increasingly become recognized as a major challenge in clinical practice for older adults. Both diabetes and hypertension worsen brain perfusion and are major risk factors for cerebrovascular disease, stroke, and dementia. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure–perfusion–cognition relationships. Endothelial dysfunction and inflammation, microvascular disease, and mascrovascular disease affect cerebral hemodynamics and play an important role in pathohysiology and severity of multiple medical conditions, presenting as cognitive decline in the old age. Therefore, the identification of cerebrovascular vascular reactivity as a new therapeutic target is needed for prevention of cognitive decline late in life.


Hemodynamics Brain atrophy Cognition Aging Blood f low Hypertension Hypotension Diabetes mellitus 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of GerontologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA

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