Diabetes and Insulin Resistance (JB Meigs and M Rutter, Section Editors)

Current Cardiovascular Risk Reports

, Volume 6, Issue 1, pp 80-90

Open Access This content is freely available online to anyone, anywhere at any time.

Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease

  • A. J. HoubenAffiliated withDepartment of Internal Medicine, Maastricht University Medical Center and Cardiovascular Research Institute MaastrichtDepartment of Internal Medicine, Maastricht University Medical Center Email author 
  • , E. C. EringaAffiliated withDepartment of Physiology, VU University medical center and Institute for Cardiovascular Research VU university medical center
  • , A. M. JonkAffiliated withDepartment of Internal Medicine, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht
  • , E. H. SerneAffiliated withDepartment of Internal Medicine, VU University medical center and Institute for Cardiovascular Research VU university medical center
  • , Y. M. SmuldersAffiliated withDepartment of Internal Medicine, VU University medical center and Institute for Cardiovascular Research VU university medical center
  • , C. D. StehouwerAffiliated withDepartment of Internal Medicine, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht

Abstract

Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysiologic link between insulin resistance and hypertension in obesity. Many studies have shown that adipose tissue-derived substances (adipokines) interact with (micro)vascular function and influence insulin sensitivity. In the past, research focused on adipokines from perivascular adipose tissue (PVAT). In this review, we focus on the interactions between adipokines, predominantly from PVAT, and microvascular function in relation to the development of insulin resistance, diabetes, and cardiovascular disease.

Keywords

Microvascular dysfunction Perivascular adipose tissue Insulin resistance Diabetes Obesity Hypertension