, Volume 5, Issue 4, pp 314-322
Date: 03 May 2011

Vitamin D, Hypertension, Left Ventricular Hypertrophy, and Diastolic Dysfunction

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Abstract

The extra-skeletal effects of vitamin D have been increasingly recognized in the recent years and its effects on blood pressure and cardiac function are areas of active investigation. This article reviews the current state of knowledge about vitamin D with respect to blood pressure and left ventricular hypertrophy. Potential biological mechanisms implicated in linking vitamin D deficiency with hypertension and cardiac dysfunction are outlined along with data from both observational and randomized controlled trials on this topic.