Current Cardiovascular Risk Reports

, Volume 5, Issue 1, pp 96-106

First online:

The Global Burden of Tobacco Use: A Review of Methods and Recent Estimates

  • Gauri KhannaAffiliated withTobacco Free Initiative, World Health Organization Email author 
  • , Gretchen StevensAffiliated withInformation, Evidence and Research, World Health Organization

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Tobacco use is a risk factor for cardiovascular, cancer, and respiratory mortality. To determine deaths attributable to tobacco, the smoking impact ratio (SIR) method is used, which measures the accumulated hazards of smoking by calculating the excess lung cancer mortality in a population, compared to lung cancer mortality in a non-smoking population. This is done to account for cross-population differences in smoking intensity and duration. Studies using SIR have also generally used relative risks of smoking-related diseases derived from the American Cancer Society’s Cancer Prevention Study to estimate the proportion of the disease attributable to tobacco use. The SIR method, while important for populations lacking high-quality epidemiological studies of the hazards of tobacco use, is still an imperfect method. Recent studies in countries such as India, China, and South Africa have estimated population-specific relative risks from reported tobacco use.


Smoking Lung cancer Mortality Risk factors