, Volume 4, Issue 4, pp 248-250
Date: 23 Apr 2010

Intensive-Therapy Glycemic Control Fails to Prevent Vascular Complications in Veterans with Type 2 Diabetes Mellitus

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Duckworth W, Abraira C, Moritz T, et al.; VADT Investigators: Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009, 360:129–139.

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• Of importance.

Introduction

Previous reports concerning prevention of cardiovascular complications in type 2 diabetes mellitus (T2DM) patients achieved through intensive glycemic control show conflicting results. When data from the old studies are re-analyzed after longer follow-up periods, their results support the notion that an intensive-therapy approach helps prevent cardiovascular complications, whereas results from newer clinical trials with shorter follow-up periods, albeit a more stringent control of additional cardiovascular risk factors, do not.

Aims

This Veterans Affairs Diabetes Trial (VADT) tests the hypothesis that intensive-therapy glycemic care in poorly controlled veterans with longstanding T2DM delays the onset of major cardiovascular events. The authors made sample size calculations based on a pl ...