The genetic determinants of common human obesity
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- Speliotes, E.K. Curr Cardio Risk Rep (2009) 3: 411. doi:10.1007/s12170-009-0061-4
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The genetic determinants of common human obesity have been elusive until recently, when work from several groups led to the identification of 16 loci that reproducibly associate with common human obesity. These loci reveal that the genetic architecture of common human obesity likely involves rare high penetrant loci, common low penetrant loci, and likely intermediate loci that are yet to be discovered. These loci implicate central nervous system processes in the pathophysiology of common human obesity, are not limited to effects in the central nervous system, and confirm a genetic susceptibility to obesity that may be harder for some individuals to overcome compared with others.