Current Cardiovascular Risk Reports

, Volume 2, Issue 6, pp 485–490

Genetic determinants of drug response in heart failure


DOI: 10.1007/s12170-008-0085-1

Cite this article as:
Lowes, B.D. & Buttrick, P.M. Curr Cardio Risk Rep (2008) 2: 485. doi:10.1007/s12170-008-0085-1


Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, β blockers, and angiotensin-converting enzyme inhibitors. Technologic advances will soon allow population-based genomewide genetic testing at a reasonable cost. Understanding the genetic factors that influence drug response in heart failure will allow physicians to personalize therapies and optimize response while minimizing serious adverse events.

Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Division of Cardiology, Campus Box B130University of Colorado Health Sciences CenterAuroraUSA