New insights into the pathogenesis and treatment of arterial aneurysms and dissections
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- Callewaert, B.L., De Paepe, A.M. & Loeys, B.L. Curr Cardio Risk Rep (2007) 1: 401. doi:10.1007/s12170-007-0066-9
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Aortic aneurysm and dissection (AAD) is a common cause of morbidity and death in the Western world. Over the last decade tremendous progress has been made in the identification of the genetic basis of aortic aneurysm syndromes. The study of rare monogenic syndromic forms of AAD can provide insights in the pathways underlying the more common nonsyndromic forms of AAD. In this paper, we describe the syndromic and nonsyndromic forms of aortic aneurysm and review the current knowledge of clinical presentation, genetic basis, pathogenesis, management, and new emerging treatment strategies.