Physical Activity and Health Outcomes Among HIV-Infected Men Who Have Sex with Men: A Longitudinal Mediational Analysis
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- Blashill, A.J., Mayer, K.H., Crane, H. et al. ann. behav. med. (2013) 46: 149. doi:10.1007/s12160-013-9489-3
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Low physical activity is associated with depression, which may, in turn, negatively impact antiretroviral therapy (ART) adherence among HIV-infected individuals; however, prior studies have not investigated the relationships between physical inactivity and ART non-adherence.
The purpose of this study was to examine the association of physical inactivity, depression, ART non-adherence, and viral load in HIV-infected men who have sex with men.
The sample (N = 860) was from a large, multicenter cohort of HIV-infected patients engaged in clinical care.
Across time, depression mediated the relationship between physical inactivity and ART non-adherence (γ = 0.075) and the relationship between physical inactivity and viral load (γ = 0.05). ART non-adherence mediated the relationship between depression and viral load (γ = 0.002) and the relationship between physical inactivity and viral load (γ = 0.009).
Low levels of physical activity predicted increased depression and poor ART adherence over time, which subsequently predicted higher viral load.