, Volume 44, Issue 1, pp 136-137,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 22 Mar 2012

A Meta-Analysis of Spurious Associations between Type D Personality and Cardiovascular Disease Endpoints

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Denollet et al. claim that high social inhibition and negative affectivity, termed type D personality, predict negative cardiovascular disease outcomes, and notably mortality [1]. Our group noted that almost all research testing this hypothesis came from small studies from Denollet’s group at Tilburg University that for mortality had 4, 6, 8, 12, and 47 deaths to explain. We conducted the largest study of mortality to date, with 192 deaths being explained, recruited patients from some of the same hospitals used by the Tilburg group, but found no association between type D personality and mortality [2]. Our primary analyses retained the component social inhibition and negative affectivity as continuous variables and tested their interaction. Secondary analyses relied upon Denollet’s preferred method of dichotomizing social inhibition and negative affectivity, creating a 2 × 2 cross-tabulation, and then comparing the high/high type D quadrant to the other three. Our results were still nu