Stress, Coping, and Circadian Disruption Among Women Awaiting Breast Cancer Surgery
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Psychological distress and coping related to a breast cancer diagnosis can profoundly affect psychological adjustment, possibly resulting in the disruption of circadian rest/activity and cortisol rhythms, which are prognostic for early mortality in metastatic colorectal and breast cancers, respectively.
This study aims to explore the relationships of cancer-specific distress and avoidant coping with rest/activity and cortisol rhythm disruption in the period between diagnosis and breast cancer surgery.
Fifty-seven presurgical breast cancer patients provided daily self-reports of cancer-specific distress and avoidant coping as well as actigraphic and salivary cortisol data.
Distress and avoidant coping were related to rest/activity rhythm disruption (daytime sedentariness, inconsistent rhythms). Patients with disrupted rest/activity cycles had flattened diurnal cortisol rhythms.
Maladaptive psychological responses to breast cancer diagnosis were associated with disruption of circadian rest/activity rhythms. Given that circadian cycles regulate tumor growth, we need greater understanding of possible psychosocial effects in cancer-related circadian disruption.
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- Stress, Coping, and Circadian Disruption Among Women Awaiting Breast Cancer Surgery
Annals of Behavioral Medicine
Volume 44, Issue 1 , pp 10-20
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- Breast cancer
- Circadian rhythm
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- Author Affiliations
- 1. Veterans Affairs Medical Center, Durham, NC, USA
- 2. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
- 3. Department of Psychological and Brain Sciences, University of Louisville, 2301 South Third Street, 317 Life Sciences, Louisville, KY, 40292, USA
- 4. Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
- 5. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
- 6. Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA
- 7. Department of Psychology, University of Kentucky, Lexington, KY, USA
- 8. Department of Pediatrics, University of Louisville, Louisville, KY, USA
- 10. James Graham Brown Cancer Center, Louisville, KY, USA
- 9. Division of Surgical Oncology, School of Medicine, University of Louisville, Louisville, KY, USA