Annals of Behavioral Medicine

, Volume 42, Issue 3, pp 321–333

Fatigue, Depression, Sleep, and Activity During Chemotherapy: Daily and Intraday Variation and Relationships Among Symptom Changes

  • Heather S. L. Jim
  • Brent Small
  • Leigh Anne Faul
  • Jamie Franzen
  • Sachin Apte
  • Paul B. Jacobsen
Original Article

DOI: 10.1007/s12160-011-9294-9

Cite this article as:
Jim, H.S.L., Small, B., Faul, L.A. et al. ann. behav. med. (2011) 42: 321. doi:10.1007/s12160-011-9294-9

Abstract

Background

Previous research suggests that cancer patients frequently experience multiple symptoms during chemotherapy; however, relationships among symptom changes are largely unknown.

Purpose

The aim of the current study was to examine daily and intraday changes and interrelationships among fatigue, depression, and objectively measured disruptions in sleep and activity during chemotherapy.

Methods

Participants were 78 women with gynecologic cancer. Fatigue, depression, sleep, and activity were assessed the week before and the week after the participants’ first three infusions.

Results

Significant changes in fatigue, depression, sleep, and activity were observed over time. Before infusions, increases in fatigue were associated with increases in depression. After infusions, increases in fatigue were associated with increases in depression and minutes awake at night, as well as decreases in daytime activity and regularity of sleep/activity patterns (ps < .05).

Conclusions

This study is among the first to track daily and intraday changes in symptoms and interrelationships during chemotherapy. Results indicate that symptoms are interrelated and return to baseline levels after infusions.

Keywords

Gynecologic cancer Fatigue Depression Actigraphy Sleep Chemotherapy 

Copyright information

© The Society of Behavioral Medicine 2011

Authors and Affiliations

  • Heather S. L. Jim
    • 1
  • Brent Small
    • 2
  • Leigh Anne Faul
    • 3
  • Jamie Franzen
    • 2
  • Sachin Apte
    • 1
  • Paul B. Jacobsen
    • 1
  1. 1.Moffitt Cancer CenterTampaUSA
  2. 2.University of South FloridaTampaUSA
  3. 3.Georgetown UniversityWashington DCUSA