Annals of Behavioral Medicine

, Volume 40, Issue 1, pp 77–88

Evaluation of a Brief Web-Based Genetic Feedback Intervention for Reducing Alcohol-Related Health Risks Associated with ALDH2

  • Christian S. Hendershot
  • Jacqueline M. Otto
  • Susan E. Collins
  • Tiebing Liang
  • Tamara L. Wall
Original Article

DOI: 10.1007/s12160-010-9207-3

Cite this article as:
Hendershot, C.S., Otto, J.M., Collins, S.E. et al. ann. behav. med. (2010) 40: 77. doi:10.1007/s12160-010-9207-3


There is increasing interest in health interventions that incorporate genetic risk information. Although genetic feedback has been evaluated as an adjunct to smoking cessation interventions, its efficacy for reducing alcohol-related risks is unknown. The purpose of this study was to evaluate the feasibility, acceptability, and efficacy of a web-based alcohol intervention incorporating genetic feedback and risk information specific to ALDH2 genotype. The ALDH2*2 variant is associated with partial protection against alcohol dependence but confers significantly increased risk for alcohol-related cancers as a function of alcohol exposure. Two hundred Asian-American young adults were randomly assigned to receive web-based personalized genetic feedback or attention-control feedback. Genetic feedback included health risk information specific to alcohol-related cancer or alcohol dependence, depending on genotype. Outcomes included postintervention drinking behavior and theoretical correlates of behavior change. Genetic feedback and risk information resulted in significant reductions in 30-day drinking frequency and quantity among participants with the ALDH2*1/*2 genotype. Genetic feedback was rated highly by participants and also showed some effects on theoretical correlates of behavior change. Results provide initial evidence of the feasibility, acceptability, and brief efficacy of web-based genetic feedback for reducing alcohol-related health risks associated with ALDH2 genotype.


Alcohol useAldehyde dehydrogenaseInterventionPersonalized feedbackGenetic feedbackInternet

Copyright information

© The Society of Behavioral Medicine 2010

Authors and Affiliations

  • Christian S. Hendershot
    • 1
    • 2
  • Jacqueline M. Otto
    • 3
  • Susan E. Collins
    • 4
  • Tiebing Liang
    • 5
  • Tamara L. Wall
    • 6
    • 7
    • 8
  1. 1.The Mind Research NetworkAlbuquerqueUSA
  2. 2.Center on Alcoholism, Substance Abuse and Addictions (CASAA)University of New MexicoAlbuquerqueUSA
  3. 3.Department of PsychologyUniversity of WashingtonSeattleUSA
  4. 4.Department of Psychiatry and Behavioral SciencesUniversity of WashingtonSeattleUSA
  5. 5.Indiana University School of MedicineIndianapolisUSA
  6. 6.Department of PsychiatryUniversity of California, San DiegoLa JollaUSA
  7. 7.Psychology ServiceVeterans Affairs San Diego Healthcare SystemSan DiegoUSA
  8. 8.Veterans Medical Research FoundationSan DiegoUSA