Annals of Behavioral Medicine

, Volume 38, Supplement 1, pp 25–30

Appetite is a Heritable Phenotype Associated with Adiposity

Original Article

DOI: 10.1007/s12160-009-9116-5

Cite this article as:
Wardle, J. & Carnell, S. ann. behav. med. (2009) 38: 25. doi:10.1007/s12160-009-9116-5

Abstract

Background

The high heritability of adiposity combined with its shifting distribution over time suggests that genetic and environmental influences interact in the etiology of adiposity.

Purpose

The purpose of this study is to examine evidence that genetically determined differences in appetite underlie variation in susceptibility to obesogenic environments.

Methods

Summary of a program of published research.

Results

Recent behavioral and psychometric studies demonstrate that appetitive characteristics such as responsiveness to internal satiety signals and external food cues not only differentiate obese and normal-weight groups, but are quantitatively associated with weight. Twin analyses show that variation in these appetitive traits is highly heritable. Sensitivity to internal satiety cues is linked with the FTO gene and mediates the association between FTO and weight.

Conclusions

These results indicate that sensitivity to internal and external appetitive signals are heritable phenotypes that increase the risk of overeating in “obesogenic” environments. A behavioral susceptibility model helps to explain how weight is both highly heritable and highly responsive to environmental characteristics.

Keywords

ObesityAppetiteWeightGenesEnvironment

Copyright information

© The Society of Behavioral Medicine 2009

Authors and Affiliations

  1. 1.Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public HealthUniversity College LondonLondonUK
  2. 2.New York Obesity Research Center, Department of Medicine, St. Luke’s-Roosevelt Hospital CenterColumbia University College of Physicians and SurgeonsNew YorkUSA