History of Unemployment Predicts Future Elevations in C-Reactive Protein among Male Participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
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Unemployment is associated with risk of future morbidity and premature mortality.
To examine whether unemployment history predicts future C-reactive protein (CRP) levels in male participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Unemployment, body mass index (BMI), and health behaviors were measured at 7, 10, and 15 years post-recruitment. CRP was measured at Years 7 and 15.
Having a history of unemployment at Year 10 was associated with higher CRP at Year 15, independent of age, race, BMI, Year 7 CRP, Year 15 unemployment, and average income across Years 10–15. Poor health practices and depressive symptoms explained 22% of the association, but Year 10 unemployment history remained a significant predictor. Findings did not differ across age, race, education, or income.
Discrete episodes of unemployment may have long-term implications for future CRP levels.
- Jin, RL, Shah, CP, Svoboda, TJ (1995) The impact of unemployment on health: A review of the evidence. CMAJ 153: pp. 529-540
- Nylén, L, Voss, M, Floderus, B (2001) Mortality among women and men relative to unemployment, part time work, overtime work, and extra work: A study based on data from the Swedish twin registry. Occup Environ Med 58: pp. 52-57 CrossRef
- Voss, M, Nylen, L, Floderus, B, Diderichsen, F, Terry, PD (2004) Unemployment and early cause-specific mortality: A study based on the Swedish twin registry. Am J Public Health 94: pp. 2155-2161
- McKee-Ryan, FM, Song, Z, Wanberg, CR, Kinicki, AJ (2005) Psychological and physical well-being during unemployment: A meta-analytic study. J Appl Psychol 90: pp. 53-76 CrossRef
- Hammarstrom, A, Janlert, U (2003) Unemployment—An important predictor for future smoking: A 14-year follow-up study of school leavers. Scand J Public Health 31: pp. 229-232 CrossRef
- Gallo, WT, Bradley, EH, Siegel, M, Kasl, SV (2000) Health effects of involuntary job loss among older workers: Findings from the health and retirement survey. J Gerontol B Psychol Sci Soc Sci 55: pp. S131-S140
- Gallo, WT, Teng, HM, Falba, TA, Kasl, SV, Krumholz, HM, Bradley, EH (2006) The impact of late career job loss on myocardial infarction and stroke: A 10 year follow up using the health and retirement survey. Occup Environ Med 63: pp. 683-687 CrossRef
- Lynge, E (1997) Unemployment and cancer: A literature review. IARC Sci Publ 138: pp. 343-351
- Lynge, E, Andersen, O (1997) Unemployment and cancer in Denmark, 1970–1975 and 1986–1990. IARC Sci Publ 138: pp. 353-359
- Bartley, M (1994) Unemployment and ill health: Understanding the relationship. J Epidemiol Community Health 48: pp. 333-337 CrossRef
- Mathers, CD, Schofield, DJ (1998) The health consequences of unemployment: The evidence. Med J Aust 168: pp. 178-182
- Roberts, H, Pearson, JCG, Madeley, RJ, Hanford, S, Magowan, R (1997) Unemployment and health: The quality of social support among residents in the Trent region of England. J Epidemiol Community Health 51: pp. 41-45
- Kessler, RC, Turner, JB, House, JS (1988) Effects of unemployment on health in a community survey: Main, modifying, and mediating effects. J Soc Issues 44: pp. 69-85 CrossRef
- Feather, NT, O’Brien, GE (1986) A longitudinal study of the effects of employment and unemployment on school-leavers. J Occup Psychol 59: pp. 121-144
- Cohen, S, Janicki-Deverts, D, Miller, GE (2007) Psychological stress and disease. JAMA 298: pp. 1685-1687 CrossRef
- Bierhaus, A, Wolf, J, Andrassy, M, Rohleder, N, Humpert, PM, Petrov, D, Ferstl, R, Eynatten, M, Wendt, T, Rudofsky, G, Joswig, M, Morcos, M, Schwaninger, M, McEwen, B, Kirschbaum, C, Nawroth, PP (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci U S A 100: pp. 1920-1925 CrossRef
- Kiecolt-Glaser, JK, McGuire, L, Robles, TF, Glaser, R (2002) Emotions, morbidity, and mortality: New perspectives from psychoneuroimmunology. Annu Rev Psychol 53: pp. 83-107 CrossRef
- Hamer, M, Williams, E, Vuonovirta, R, Giacobazzi, P, Gibson, EL, Steptoe, A (2006) The effects of effort-reward imbalance on inflammatory and cardiovascular responses to mental stress. Psychosom Med 68: pp. 408-413 CrossRef
- McDade, TW, Hawkley, LC, Cacioppo, JT (2006) Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: The Chicago Health, Aging, and Social Relations Study. Psychosom Med 68: pp. 376-381 CrossRef
- Suarez, EC, Krishnan, RR, Lewis, JG (2003) The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. Psychosom Med 65: pp. 362-368 CrossRef
- Danesh, J, Whincup, P, Walker, M (2000) Low-grade inflammation and coronary heart disease: Prospective study and updated meta-analyses. BMJ 321: pp. 199-204 CrossRef
- Dziedzic, T (2006) Systemic inflammatory markers and risk of dementia. Am J Alzheimer Dis Dement 21: pp. 258-262 CrossRef
- Ross, R (1999) Mechanisms of disease: Atherosclerosis—An inflammatory disease. NEJM 340: pp. 115-126 CrossRef
- Pickup, JC, Crook, MA (1998) Is type II diabetes mellitus a disease of the innate immune system?. Diabetologia 41: pp. 1241-1248 CrossRef
- Pradhan, AD, Manson, JE, Rifai, N, Buring, JE, Ridker, PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286: pp. 327-334 CrossRef
- Cutter, GR, Burke, GL, Dyer, AR, Friedman, GD, Hilner, JE, Hughes, GH, Hulley, SB, Jacobs, DRJ, Liu, K, Monolio, TA, Oberman, A, Perkins, LL, Savage, PJ, Serwitz, JR, Sidney, S, Wagenknecht, LE (1991) Cardiovascular risk factors in young adults: The CARDIA baseline monograph. Control Clin Trials 12: pp. 1s-77s CrossRef
- Friedman, GD, Cutter, GR, Donahue, RP, Hughes, GH, Hulley, SB, Jacobs, DRJ, Liu, K, Savage, PJ (1988) CARDIA: Study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol 41: pp. 1105-1116 CrossRef
- Buhmann, B, Rainwater, L, Schmaus, G, Smeeding, TM (1988) Equivalence scales, well-being, inequality, and poverty: Sensitivity estimates across ten countries using the Luxembourg Income Study (LIS) database. Rev Income Wealth 34: pp. 115-142 CrossRef
- Radloff, LS (1977) The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Measurement 1: pp. 385-401 CrossRef
- Bromberger, JT, Matthews, KA (1996) A “feminine” model of vulnerability to depressive symptoms: A longitudinal investigation of middle-aged women. J Pers Soc Psychol 70: pp. 591-598 CrossRef
- Cohen, S, Schwartz, JE, Epel, ES, Kirschbaum, C, Sidney, S, Seeman, T (2006) Socioeconomic status, race, and diurnal cortisol decline in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Psychosom Med 68: pp. 41-50 CrossRef
- The University of Alabama at Birmingham DoPM. Coronary Artery Risk Development in Young Adults (CARDIA) Study. Available at: http://www.cardia.dopm.uab.edu/o_brde.htm. Accessibility verified March 15, 2006.
- Jacobs, DR, Hahn, L, Haskell, WL, Pirie, P, Sidney, S (1989) Validity and reliability of a short physical activity history: CARDIA and the Minnesota Heart Health Program. J Cardiopulm Rehabil 9: pp. 448-459 CrossRef
- Shine, B, Beer, FC, Pepys, M (1981) Solid phase radio-immunoassays for C-reactive protein. Clin Chem Acta 117: pp. 13-23 CrossRef
- U.S. Census Bureau. Educational attainment: 2000. Available at: www.census.gov/prod/2003pubs/c2kbr-24.pdf. Accessibility verified March 5, 2007.
- U.S. Census Bureau. Household income: 1999. Available at: www.census.gov/prod/2005pubs/c2kbr-36.pdf. Accessibility verified March 5, 2007.
- Rohde LE, Hennekens CH, Ridker PM. Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men. Am J Cardiol. 1999; 84.
- Schnorpfeil, P, Noll, A, Schulze, R, Ehlert, U, Frey, K, Fischer, JE (2003) Allostatic load and work conditions. Soc Sci Med 57: pp. 647-656 CrossRef
- Ranjit, N, Diez-Roux, AV, Shea, S, Cushman, M, Seeman, T, Jackson, SA, Ni, H (2007) Psychosocial factors and inflammation in the multi-ethnic study of atherosclerosis. Arch Intern Med 167: pp. 174-181 CrossRef
- Miller, GE, Cohen, S, Ritchey, AK (2002) Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model. Health Psychol 21: pp. 531-541 CrossRef
- Cassidy, T, Wright, L (2008) Graduate employment status and health: A longitudinal analysis of the transition from student. Soc Psychol of Educ 11: pp. 181-191 CrossRef
- Block, G, Dietrich, M, Norkus, E, Jensen, C, Benowitz, NL, Morrow, JD, Hudes, M, Packer, L (2006) Intraindividual variability of plasma antioxidants, markers of oxidative stress, C-reactive protein, cotinine, and other biomarkers. Epidemiology 17: pp. 404-412 CrossRef
- History of Unemployment Predicts Future Elevations in C-Reactive Protein among Male Participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Annals of Behavioral Medicine
Volume 36, Issue 2 , pp 176-185
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- C-reactive protein
- Socioeconomic status
- Health behaviors
- Industry Sectors
- Author Affiliations
- 1. Department of Psychology, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA
- 2. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, USA
- 3. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06510, USA