Annals of Behavioral Medicine

, Volume 36, Issue 2, pp 176–185

History of Unemployment Predicts Future Elevations in C-Reactive Protein among Male Participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

  • Denise Janicki-Deverts
  • Sheldon Cohen
  • Karen A. Matthews
  • Mark R. Cullen
Original Article

DOI: 10.1007/s12160-008-9056-5

Cite this article as:
Janicki-Deverts, D., Cohen, S., Matthews, K.A. et al. ann. behav. med. (2008) 36: 176. doi:10.1007/s12160-008-9056-5



Unemployment is associated with risk of future morbidity and premature mortality.


To examine whether unemployment history predicts future C-reactive protein (CRP) levels in male participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.


Unemployment, body mass index (BMI), and health behaviors were measured at 7, 10, and 15 years post-recruitment. CRP was measured at Years 7 and 15.


Having a history of unemployment at Year 10 was associated with higher CRP at Year 15, independent of age, race, BMI, Year 7 CRP, Year 15 unemployment, and average income across Years 10–15. Poor health practices and depressive symptoms explained 22% of the association, but Year 10 unemployment history remained a significant predictor. Findings did not differ across age, race, education, or income.


Discrete episodes of unemployment may have long-term implications for future CRP levels.


Unemployment C-reactive protein Socioeconomic status Health behaviors 

Copyright information

© The Society of Behavioral Medicine 2008

Authors and Affiliations

  • Denise Janicki-Deverts
    • 1
  • Sheldon Cohen
    • 1
  • Karen A. Matthews
    • 2
  • Mark R. Cullen
    • 3
  1. 1.Department of PsychologyCarnegie Mellon UniversityPittsburghUSA
  2. 2.Department of PsychiatryUniversity of PittsburghPittsburghUSA
  3. 3.Department of Internal MedicineYale University School of MedicineNew HavenUSA

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