Annals of Behavioral Medicine

, 35:198

Spirituality and Autonomic Cardiac Control

Authors

    • Ohio State University
  • Greg J. Norman
    • Ohio State University
  • Louise C. Hawkley
    • The University of Chicago
  • John T. Cacioppo
    • The University of Chicago
Original Article

DOI: 10.1007/s12160-008-9027-x

Cite this article as:
Berntson, G.G., Norman, G.J., Hawkley, L.C. et al. ann. behav. med. (2008) 35: 198. doi:10.1007/s12160-008-9027-x

Abstract

Background

Spirituality has been suggested to be associated with positive health, but potential biological mediators have not been well characterized.

Purpose and Methods

The present study examined, in a population-based sample of middle-aged and older adults, the potential relationship between spirituality and patterns of cardiac autonomic control, which may have health significance. Measures of parasympathetic (high-frequency heart rate variability) and sympathetic (pre-ejection period) cardiac control were obtained from a representative sample of 229 participants. Participants completed questionnaires to assess spirituality (closeness to and satisfactory relationship with God). Personality, demographic, anthropometric, health behavior, and health status information was also obtained. A series of hierarchical regression models was used to examine the relations between spirituality, the autonomic measures, and two derived indexes—cardiac autonomic balance (CAB, reflecting parasympathetic to sympathetic balance) and cardiac autonomic regulation (CAR, reflecting total autonomic control).

Results

Spirituality, net of demographics, or other variables were found to be associated with enhanced parasympathetic as well as sympathetic cardiac control (yielding a higher CAR) but was not associated with CAB. Although the number of cases was small (N = 11), both spirituality and CAR were significant negative predictors of the prior occurrence of a myocardial infarction.

Conclusions

In a population-based sample, spirituality appears to be associated with a specific pattern of CAR, characterized by a high level of cardiac autonomic control, irrespective of the relative contribution of the two autonomic branches. This pattern of autonomic control may have health significance.

Keywords

SpiritualitySympatheticParasympathetic pre-ejection periodHeart rate variabilityCardiac controlAutonomic balanceMyocardial infarction

Introduction

Cardiovascular disease is the leading cause of mortality and morbidity in the USA, and more than 1 million Americans suffer a myocardial infarction each year (National Center for Health Statistics, see [1]), and psychosomatic factors increasingly appear to play an important role in the development of cardiovascular pathology. The relationship between psychological states or processes and health has long been studied, and the distinguished physiologist Walter Cannon speculated on a specific physiological mechanism that may underlie what he termed “Voodoo” death [2]. More recently, a hypersympathetic state associated with psychological stress has been implicated in what has been variously termed takosubo cardiomyopathy, myocardial stunning, human stress cardiomyopathy, or broken heart syndrome [3]. These and other developments have led to the expansion of the field of neurocardiology and the recent establishment of the Society of Heart Brain Medicine (see [4]). It is now clear that a wide variety of psychological and behavioral variables may powerfully impact autonomic control and even distinct patterns of sympathetic and parasympathetic regulation [5, 6]. Consequently, it is important to clarify the specific role of psychological variables in health and disease. Although the concept of stress has become prominent in the prior literature, a more recent focus has been on resilience and potential mediators of positive health impact (e.g., [7]).

In this regard, although limitations and caveats exist [8], there is now a growing literature suggesting that religiosity and/or spirituality may be associated with positive health outcomes, especially cardiovascular health [915]. Although many of these studies are cross-sectional and correlational, making causal linkages difficult to establish, there are ample behavioral, physiological, endocrinological, and immunological pathways through which spirituality and religiosity might impact health [12, 1619]. Moreover, longitudinal/prospective, experimental, and clinical intervention studies do suggest some causal linkages between spirituality or spiritual practices and autonomic cardiovascular control and health [13, 15, 20].

Religious service attendance is the aspect of religiosity that has most often been examined in relation to health outcomes and has been shown to predict a lower risk of cardiovascular and coronary heart disease mortality in well-designed prospective studies [21-23]. Religious service attendance, however, is a global index that does not illuminate what it is about religiosity that might explain its association with health outcomes [24]. Accordingly, researchers have employed more specific measures of religious and spiritual beliefs and experiences and have shown physical and/or mental health benefits associated with subjective assessments of religious support [25], religious coping [26], religious orientation [27], and perceived closeness to God [28].

This latter aspect of religiosity/spirituality, closeness to God, implies a relationship with God, a relationship that may have its roots in sociality [16] and may therefore be usefully studied in that context. The evolutionary motive of the social human species to form and maintain attachments, interpersonal relationships, and collectives, which is in part genetically determined [29], contributes to the capacity for humanity and spirituality with which people are born [30]. Moreover, the human tendency to form social connections extends beyond kin and includes real and imagined others [31]. The feeling of social connectedness and purpose that comes from a relationship with a higher being or God is a potent component of what we refer to as “spirituality” (as distinguished from religiosity, which we will use to refer to more objective measures such as church service attendance; [24]). The conceptualization of spirituality as a relationship between an individual and God links this work with an extensive scientific literature on the effects of interpersonal connections on physiology, health, and well-being [3236].

Over a century ago, William James pointed to the need for psychophysical theory concerning the potential relation between spiritual values and “determinate sorts of physiological change” [37]. Some potential mediators of relations between spirituality and cardiovascular health, such as smoking [19], diet [38], or other health-related behaviors [39], are transparent and may not require theoretical explication. Others, however, may benefit from a more theoretical grounding and conceptual modeling of the relevant physiological dimensions that underlie health relationships. This is the case for possible autonomic nervous system mediators of potential relations between spirituality and cardiovascular regulation and health.

Certain spiritual or meditation practices have been reported to be associated with increased parasympathetic and decreased sympathetic cardiac control [40, 41]. Such a pattern of autonomic control could be a potential mediator of spirituality and health outcomes. High sympathetic cardiac control, for example, is a known risk factor for myocardial infarction and for survival thereafter [4246], and a hypersympathetic state appears to underlie human stress cardiomyopathy [47]. Indeed, drugs that block sympathetic actions (primarily beta-adrenergic blockers) are a common treatment strategy after myocardial infarction [46]. In contrast, the parasympathetic system exerts antifibrillary actions [42], and low parasympathetic activity is a predictor of negative outcomes after myocardial infarction [43, 47].

From these considerations, a dimension of autonomic control that may be relevant to cardiovascular health is the relative balance between sympathetic and parasympathetic cardiac regulation. The autonomic balance model has a long history. Eppinger and Hess [48] proposed that individuals are constitutionally disposed toward a predominance of either sympathetic (sympathicotonia) or parasympathetic (vagotonia) control and that these physiological predilections may bias toward distinct psychosomatic disorders (e.g., hypertension and asthma, respectively). Wenger [49] subsequently confirmed aspects of the findings of Eppinger and Hess, but their proposed autonomic balance metric (\(\bar A\)) was characterized by a continuous, normal distribution rather than a dichotomous categorical variable.

The autonomic balance model continues to be represented in the contemporary literature, both as an individual difference characteristic and as a predictor of health outcomes. A current example is the proposed autonomic balance metric derived from measures of heart rate variability [50, 51]. Specifically, high-frequency (HF) heart rate variability, in the respiratory frequency band, provides a relatively pure index of parasympathetic cardiac control, whereas low-frequency (LF) variability reflects a combination of sympathetic and parasympathetic influences (see [5254]). Based on this and other empirical findings, Malliani et al. suggest that a ratio of LF to HF variability indexes the relative autonomic balance, along a continuum from sympathetic to parasympathetic predominance [50, 51]. Although this metric has been challenged on both conceptual and empirical grounds [55], it continues to be widely employed as a metric of sympathovagal balance.

Although there may well be individual differences in the relative contributions of sympathetic and parasympathetic branches, it is not at all clear that sympathovagal balance is a physiologically regulated dimension. Moreover, despite powerful homeostatic controls over cardiovascular parameters such as blood pressure, it is clear that even regulated dimensions are not characterized by fixed, invariant levels. Rather, it is alterations in these dimensions (blood pressure, heart rate, myocardial contractility, etc.) that permit an adaptive cardiovascular response to perturbations such as orthostatic stress, exercise, or fight/flight responses. This pattern of regulatory flexibility has been termed allostatic [56, 57] or allodynamic [6] regulation and is conceptualized as a means of achieving “stability through change” ([58], p. 631). According to this view, the critical dimension of autonomic regulation may be not so much autonomic balance but autonomic flexibility or regulatory capacity that permits an organism to adaptively deal with changing demands.

In this regard, diminished HF heart rate variability, reflective of lower parasympathetic cardiac control, has been reported to be a significant risk stratifier for recovery following myocardial infarction [54, 5962] and is also a predictor of hypertension after controlling for age and other risk factors [63]. However, it is also the case that diminished LF variability (which includes sympathetic contributions) may be an equivalent or superior risk stratifier [54, 6062] and is also predictive of the development of hypertension [64]. These findings suggest that the relevant predictive authority may derive not so much from a change in autonomic balance but from an overall reduction in autonomic flexibility or variability. This is in keeping with the suggestion that autonomic irregularity, rather than a regulatory fixedness, may be the more relevant parameter in cardiovascular health [65]. In this regard, Hemingway et al. [66] reported that low heart rate variability may be a critical mediator of the relation between low social status and increased cardiac risk. Moreover, these authors find that diminished LF power is a potent component of metabolic syndrome, which in turn is a cardiac risk factor.

Low overall heart rate variability is not linked just with cardiovascular disorders but has been reported to be a risk factor for all cause mortality and morbidity [67, 68]. Moreover, reduced “autonomic flexibility,” reflected by low heart rate variability, has been reported under conditions as disparate as anxiety and dyspepsia [6972]. These findings raise an additional or an alternative possibility to the sympathovagal balance model. A relevant health determinant may be the overall regulatory capacity, which supports flexible adjustments in the face of adaptive challenges.

The present study examines the links between a specific aspect of spirituality, namely satisfaction with the God relationship, and autonomic control in a population-based sample [73], from the standpoint of two models. The first is the autonomic balance model, associated with a regulated autonomic endpoint (narrow range of variability), and the other being the autonomic regulation model, associated with a regulatory capacity (wide range of variability). The present study employs two metrics to evaluate this contrast. Pre-ejection period (PEP) is employed as a measure of sympathetic cardiac control [74-76], and HF heart rate variability is employed as a metric of parasympathetic control [51-53]. Cardiac autonomic balance (CAB) is operationalized as the difference between the (normalized) sympathetic and parasympathetic measures, and overall Cardiac Autonomic Regulation (CAR) is taken as the sum of sympathetic and parasympathetic cardiac controls.

Materials and Methods

Study Population

Data for this study were collected in years 1–3 of the Chicago Health, Aging, and Social Relations Study, a longitudinal, population-based study of persons born between 1935 and 1952. The target population was non-Hispanic Caucasian, African American, and non-Black Latino American persons between the ages of 50 an 68 living in Cook County, IL, USA, who were English speaking and sufficiently ambulatory to come to the University of Chicago for a daylong visit to the laboratory. The sample was selected using a multistage probability design in which African Americans and Latino Americans were oversampled and gender equality maintained. Data for individual participants were averaged over the 3-year period, to increase reliability. In cases where data points were missing from 1 or 2 years, the participant’s score was based on the available data. Across variables, 60–83% of the participant’s had scores for all 3 years, and 88–89% had scores for at least 2 years. The final sample size was 229.

Procedure

Participants arrived at the laboratory between 8 a.m. and 9 a.m. They provided informed consent and then began a day of assessments that included standard psychological surveys, interviews, lunch, and a cardiovascular protocol.

Cardiovascular activity was measured prior to lunch for all participants. Experimenters attached sensors for electrocardiograph, impedance cardiograph, and blood pressure recording. Participants were then seated in a comfortable padded chair. During a 15-min adaptation period, participants completed questionnaires while experimenters established good signal quality. Participants then sat quietly for an additional 5 min prior to recording baseline cardiovascular activity (4 min).

Cardiovascular Measures

Primary cardiovascular measures of sympathetic and parasympathetic cardiac control, respectively, were PEP and HF (0.15–0.4 Hz) heart rate variability. PEP, derived from impedance cardiography, is commonly used as a measure of sympathetic cardiac control [7476]. HF heart rate variability is a rhythmical fluctuation of heart rate in the respiratory frequency band (respiratory sinus arrhythmia) and has been shown to be a relatively pure index of parasympathetic control (see [5254]).

The electrocardiogram was obtained using the standard lead II configuration. The impedance cardiogram was obtained using the standard tetrapolar electrode system, and procedures are described elsewhere [76]. The electrocardiogram and basal thoracic impedance (Z0) were measured using a Biopac MP100 system (ECG100 and EB1100 modules, respectively; Biopac Systems, Santa Barbara, CA, USA). The electrocardiogram and Z0 were digitized at 1,000 Hz.

Custom software (Mindware, Gahanna, OH, USA) was used to generate the dZ/dt waveform necessary to obtain impedance-derived measures (i.e., PEP). The same software was used to verify, edit, and summarize cardiovascular data. For each subject, electrocardiograph and impedance data were ensemble averaged for each minute to produce estimates of the PEP. PEP was quantified as the time interval in milliseconds from the onset of the electrocardiogram Q wave to the B point of the dZ/dt wave [76]. Minute-by-minute means were then averaged over the 4-min baseline period.

HF heart rate variability was derived by spectral analysis (Fast Fourier transform, Mindware, Gahanna, OH, USA) of the interbeat interval series derived from the electrocardiogram, following procedures specified by Berntson et al. [53]. Briefly, the RR interval series was time sampled at 4 Hz (with interpolation) to yield an equal interval time series. This time series was detrended (second-order polynomial), end-tapered, and submitted to a Fast Fourier transform. HF spectral power was then integrated over the respiratory frequency band (0.15–0.4 Hz). Respiratory measures were also obtained to ensure that the respiratory rates were within the analytical band. If respiratory rates fell below the HF cutoff, data from that minute were excluded from analysis. This was an issue in only two cases and, for each, resulted in a single minute (of 4) being excluded. Further preliminary analyses were pursued to ensure that respiratory parameters did not covary with and potentially bias experimental variables. Neither respiratory frequency nor respiratory depth was correlated with any of the major variables (spirituality, CAB, or CAR; for all correlations, r < 0.10, p > 0.15).

Two measures of autonomic control were derived from HF and PEP. An index of autonomic balance, CAB, was derived as the difference between normalized values of parasympathetic control (HF) and sympathetic control (PEP). A metric of overall CAR was derived as the sum of the normalized values of HF and PEP. Normalization of values was necessary because of the wide differences in means and scaling among the HF and PEP measures. Normalization was accomplished by transforming values to z scores, so all normalized values are expressed in standard deviations relative to the population means. In addition, because increased sympathetic control is associated with shortened PEP values, PEP was multiplied by −1 (−PEP), to invert the relationship to a positive association. Consequently, CAB = HFz − (−PEPz) and CAR = [HFz + (−PEPz)].

As an ancillary analysis, we also derived LF heart rate variability (0.05–0.15 Hz). Both sympathetic and parasympathetic branches contribute to variability at this frequency, but the LF/HF ratio has been proposed as a measure of sympathovagal balance [50, 51]. Although this metric has been challenged on both conceptual and empirical grounds [53, 55], it continues to be employed as a metric of sympathovagal balance. For completeness, we also include it here.

Religiosity, Spirituality, and Psychological Measures

Religiosity

Religious service attendance was represented by five categories ranging from 0 (never) to 4 (more than once a week). Attendance was averaged across all 3 years.

Religious Well-being

Religious well-being scores were derived from the relevant ten items of the 20-item spiritual well-being scale [77]. Religious well-being is represented by items such as “I believe that God loves me and cares about me” and “My relationship with God helps me not to feel lonely.” Participants were asked to rate the extent of their agreement with each item on a Likert scale ranging from 1 (strongly agree) to 6 (strongly disagree). Negatively worded items were reverse scored, and responses were summed to generate a religious well-being score. See Paloutzian and Ellison [77] for scale design and psychometric properties. Religious well-being scores were averaged across all 3 years.

Multidimensional Relationship Satisfaction

This is a self-report questionnaire we designed to assess, on a common metric, participants’ ratings of their relationship with (1) the single most important person in their life, (2) the single most important group to which they belong, (3) their pet or pets, and (4) God. Within each relationship category, participants are asked to what extent (a) they feel this relationship is satisfying and (b) this relationship effectively serves as a refuge, a source of safety, security, and consolation, and as a shelter from danger or trouble. Responses were made on a Likert scale that ranged from 0 (not at all) to 7 (very much). Only those who responded affirmatively to a belief in God were asked to respond to the follow-up questions for that item. The means of the responses within each relationship category were used to create measures of person satisfaction, group satisfaction, pet satisfaction, and satisfaction with God.

Aggregate Measure of Spirituality

Because the measure of religious well-being was highly correlated with satisfaction with God (r[226] = 0.84, p ≤ 0.001), we aggregated these two measures by summing the z score transforms of each for an aggregate spirituality (AS) measure.

Big “Three” (Big3)

To examine personality characteristics that may mediate potential relations between spirituality and other variables, participants also completed three of the Big5 personality scales [78]. This is a self-report questionnaire in which participants are asked to rate how accurately each of 100 trait words describes how they see themselves at the present using a nine-point Likert scale that ranges from 1 (extremely inaccurate) to 9 (extremely accurate). The 100-items represent five personality subscales consisting of ten positive and ten negative items each. A 60-item version of this scale was used to assess surgency (extraversion), agreeableness, and emotional stability (neuroticism). Scores on these subscales were computed by reverse scoring the negative items (items phrased so that a low score indicates a high endorsement of the item) in each factor and then finding the mean item response for all 20 items. This yields subscale scores with ranges of 1 to 9; scores above 5 mean that the subject viewed the positive aspects of the factor as being more accurate in descriptions of herself/himself, while a score below five means the negative aspects were viewed as more descriptive.

Psychosocial Characteristics

Standardized questionnaires for loneliness (revised University of California—Los Angeles Loneliness Scale; [79]), perceived stress (Perceived Stress Scale; [80]), social support (Interpersonal Support Evaluation List; [81]), hostility (Cook Medley Hostility Scale; [82]), and depressive symptoms (Center for Epidemiological Studies Depression Survey; [83]) were used to measure psychosocial characteristics that might be confounded with spirituality and account for an association between spirituality and autonomic cardiac control.

Covariates

Demographic covariates were gender, ethnicity, age, education (years of schooling), and household income. Household income was reported in 12 categories ranging from less than 5,000 to more than 200,000; to achieve a more continuous distribution, we used the log-transformed median of each category in analyses. Missing values for education (six subjects) and household income (13 subjects) were replaced with means from the corresponding gender by ethnic group combination.

Body mass index, calculated as weight in kg/(height in m)2, served as a covariate in analyses of cardiovascular and health status variables. Forty percent of participants were on vasoactive medications, 5% were on volume active medications, and an additional 11% were on both types of medication. The likelihood of being on cardiovascular medications did not differ as a function of spirituality (r[225] = −0.008, p = 0.91). However, spirituality may influence participants’ likelihood of complying with medication regimens. Holding cardiovascular medications constant permits an assessment of the independent effects of the spirituality factors. All reported effects were not changed by the addition of any covariates.

Health behaviors, including smoking (yes/no), exercise (some/none), and having visited a physician within the past year (yes/no), were included to examine whether these health behaviors account for associations between spirituality and autonomic as well as health outcomes. Total endorsement of adverse health conditions (diabetes, arthritis, Alzheimer’s, stroke, myocardial infarction, cancer, and human immunodeficiency virus infection) were also tabulated to provide an overall index of health status.

Data Analysis

A set of linear regression models was used to test associations between spirituality and the cardiac autonomic measures and whether these associations withstood statistical control for demographic characteristics (i.e., age, gender, ethnicity), psychosocial characteristics, health status, medications, health behaviors, and personality traits known or likely to influence the outcome measures. Logit regression was employed for the analysis of myocardial infarction, which was coded either as a yes or no. All continuous predictor variables were standardized to a mean of zero and a standard deviation of 1 to represent potentially substantive individual differences in these characteristics.

Path analysis was employed to evaluate potential mediation effects according to the general methods outlined by Baron and Kenny [84] and MacKinnon et al. [85]. Specifically, a bootstrapping procedure was employed to obtain estimates and confidence intervals for indirect effects [86].

Results

Participant Characteristics

Demographic and other characteristics of the participants and the sample are illustrated in Table 1. Table 2 shows the spirituality scores and autonomic parameters by age and gender, as well as for participants with and without a prior myocardial infarction. More than 95% of the sample professed a belief in God, and religious preferences were divided among Protestants (38.4%), Roman Catholics (43.7%), others (Jewish, Orthodox, others; 10%), and no preference (7.9%).
Table 1

Participant characteristics at baseline (Means ± SEM or percentages)

 

Overall (n = 229)

Men (n = 109)

Women (n = 120)

Age

57.43 ± (0.29)

57.53 ± (0.46)

57.34 ± (0.39)

Income ($)

67,122 ± (3,829)

77,875 ± (6,025)

57,501 ± (4,700)

Education

13.27 ± (0.21)

13.16 ± (0.31)

13.37 ± (0.28)

Married/cohabitating

140 (61%)

82 (75%)

58 (48%)

Body mass index

31.50 ± (0.46)

31.17 ± (0.61)

31.81 ± (0.69)

Caucasians

82 (36%)

39 (36%)

43 (36%)

African Americans

81 (36%)

37 (34%)

44 (37%)

Hispanics

66 (28%)

33 (30%)

33 (28%)

Table 2

Autonomic and religious values across age, gender, and presence/absence of a prior myocardial infarction Mean ± (SEM)

 

RSA

PEP

CAR

AR

Age 50–57 (n = 66)

5.11 ± (0.11)

102.29 ± (1.43)

.12 ± (0.10)

−0.14 ± (0.18)

Age 58–68 (n = 90)

4.86 ± (0.11)

103.68 ± (1.34)

−0.12 ± (0.08)

0.14 ± (0.17)

Men (n = 109)

4.81 ± (0.11)

104.95 ± (1.57)

−0.22 ± (0.10)

−0.52 ± (0.19)

 50–57 (n = 52)

4.77 ± (0.15)

103.08 ± (2.49)

−0.18 ± (0.14)

−0.52 ± (0.32)

 58–68 (n = 57)

4.86 ± (0.16)

106.83 ± (1.96)

−0.26 ± (0.12)

−0.52 ± (0.25)

Women (n = 120)

5.15 ± (0.11)

101.53 ± (1.18)

0.20 ± (0.08)

0.52 ± (0.14)

 50–57 (n = 63)

5.42 ± (0.14)

101.56 ± (1.63)

0.36 ± (0.12)

0.25 ± (0.19)

 58–68 (n = 57)

4.88 ± (0.15)

100.51 ± (1.73)

0.04 ± (0.12)

0.79 ± (0.18)

MI (n = 11)

4.09 ± (0.37)

117.5 ± (4.58)

−1.02 ± (0.16)

−1.43 ± (0.81)

No-MI (n = 218)

5.03 ± (0.08)

103.4 ± (0.98)

0.04 ± (0.06)

0.60 ± (0.12)

Spirituality Predicts Cardiac Autonomic Regulatory Capacity

Initial analyses examined the relationship between spirituality and two general models of autonomic cardiac control, the regulatory capacity model (CAR) and the autonomic balance model (CAB). CAR provides an aggregate index of total or summed autonomic control across autonomic branches (HFz + [−PEPz]). CAB indexes a classical model of autonomic balance expressed along a continuum extending from parasympathetic to sympathetic dominance [(HFz − (−PEPz]).

Cardiac Autonomic Regulation

The distribution of CAR scores across age and gender is illustrated in Fig. 1. A significant correlation was observed between the spirituality index (AS) and CAR (r[219] = 0.25, p ≤ 0.001). To examine this relation further, demographic and other covariates were held constant in linear regression models predicting CAR. Independent of age, gender, ethnicity, and cardiovascular medications, AS retained significant associations with CAR, accounting for an additional 4% of the variance in this index (B = 0.10; Beta = 0.21; t[192] = 2.87, p = 0.005; overall model R2 = 0.14, F[?, 192] = 3.83, p ≤ 0.001; effect size = 0.04).
https://static-content.springer.com/image/art%3A10.1007%2Fs12160-008-9027-x/MediaObjects/12160_2008_9027_Fig1_HTML.gif
Fig. 1

Cardiac autonomic regulation (CAR), as a function of age (median split) and gender. Overall, women show higher CAR scores than men, and these decrease for both genders with age

Spirituality remained a significant predictor of CAR, even after holding constant body mass index, blood pressure, cardiovascular medications, health status, and health behaviors. It also continued to predict CAR after entry of the Big3 personality variables (surgency [mean = 5.74 ± 0.94 SD], agreeableness [7.03 ± 0.80], and emotional stability [5.58 ± 0.90]) into the equation. The predictive relationship between spirituality and CAR also was not attributable to potential associated psychosocial characteristics including loneliness (35.82 ± 9.01), perceived stress (12.81 ± 5.51), social support (12.81 ± 1.92), hostility (17.14 ± 7.34), or depression (10.06 ± 7.83). None of these latter variables were significantly correlated with CAR, and the relationship between spirituality and autonomic regulation survived prior entry of each of these variables into the regression equation. Similarly, the relationship between spirituality and autonomic regulation was not attributable to a general satisfaction with personal relationships (as measured by the Multidimensional Relationship Satisfaction scale).

As expected, spirituality was correlated with religious service attendance (r[225] = 0.51, p ≤ 0.001), and religious service attendance was also correlated with CAR (r[223] = 0.15, p = 0.03). The measure of spirituality, however, appeared to reflect more of a psychological state, rather than the behavioral manifestation, as religious service attendance did not significantly predict CAR in a regression analysis holding demographics and body mass index constant (R2 change = 0.01, p = 0.13).

Cardiac Autonomic Balance

In contrast, spirituality was not a significant predictor of CAB. We also evaluated another metric, the LF/HF ratio, which has also been suggested to be a marker of autonomic balance [50, 51]. Although there was a significant correlation between spirituality and the LF/HF ratio (r[219] = 0.23, p = 0.001), spirituality was not a significant predictor when demographics and body mass index were held constant.

Spirituality Predicts Autonomic Cardiac Control

Parasympathetic Cardiac Control (HF Heart Rate Variability)

The aggregate index of spirituality was positively correlated with parasympathetic cardiac control as indexed by HF heart rate variability (r[222] = 0.151, p = 0.02). Regression analyses further revealed that spirituality was a significant predictor of HF, net of demographic variables, accounting for an additional 2% of the variance in HF heart rate variability (B = 0.09; Beta = 0.21; t[222] = 2.06, p = 0.04; effect size = 0.02).

Spirituality continued to predict HF after other autonomic (PEP, blood pressure) and personality (Big3) variables were entered into the equation. Similarly, spirituality continued to significantly predict HF after holding constant health behaviors, body mass index, health status, and cardiovascular medications.

Sympathetic Cardiac Control (PEP)

Spirituality was also positively correlated with sympathetic cardiac control indexed (inversely) by PEP (r[222] = −0.18, p = 0.009). Consistent with the findings for CAR, this suggests that spirituality may be associated with increased autonomic cardiac control regardless of its parasympathetic or sympathetic source. Regression analyses further revealed that spirituality was a significant predictor of PEP, net of demographic variables, accounting for an additional 2% of the variance in PEP (B = −1.12; Beta = −0.14; t[195] = 1.98, p = 0.05; effect size = 0.02).

Spirituality continued to predict PEP after other autonomic measures (HF heart rate variability, blood pressure), psychosocial characteristics, and personality (Big3) variables were entered into the equation. Similarly, spirituality continued to significantly predict PEP after holding constant health behaviors, body mass index, health status, and cardiovascular medications. The distributions of HF and PEP scores across age and gender are illustrated in Fig. 2.
https://static-content.springer.com/image/art%3A10.1007%2Fs12160-008-9027-x/MediaObjects/12160_2008_9027_Fig2_HTML.gif
Fig. 2

Distribution of the high frequency heart rate variability (HF) and for pre-ejection period (PEP) across age (median split) and gender. HF is in units of squared milliseconds (natural log of the integral spectral power in the respiratory frequency band), and PEP is in units of milliseconds. Women have generally higher HF values (reflecting paraympathetic cardiac control) than men, and these values tended to decrease with age. Women also had lower PEP values (indexing sympathetic cardiac control) than men, and these values also tended to decrease with age

Prior Myocardial Infarction is Associated with Patterns of Autonomic Cardiac Control

Eleven of 229 participants reported having had a heart attack or myocardial infarction (7 of 109 men, 4 of 120 women). A significant negative (point biserial) correlation was observed between spirituality and myocardial infarction (r[226] = −0.14, p = 0.035). A logit regression was used to predict previous occurrence of myocardial infarction from spirituality, net of demographics. Spirituality was found to be a significant predictor of myocardial infarction, with demographics (age, gender, marital status, education, and income) and BMI held constant. For every one unit increase in AS, the odds of a myocardial infarction decreased by a factor of 0.62 (B = −0.48, Wald = 5.21, p = 0.02, 95% CI 0.41–0.94). Spirituality continued to significantly predict myocardial infarction after holding constant church attendance, psychosocial characteristics, health behaviors, body mass index, health status, and cardiovascular medications. The interpretation of this relationship is unclear, however, as the occurrence of a myocardial infarction may have impacted spirituality. We will return to this issue below.

Cardiac Autonomic Regulation

Overall cardiac autonomic control was also negatively correlated with the prior occurrence of a heart attack, (r[229] = −0.26, p < 0.001). A logit regression revealed that CAR was a significant negative predictor of myocardial infarction, with demographics (age, gender, marital status, education, and income) and body mass index held constant. For every one unit increase in CAR, the odds of a myocardial infarction decreased by a factor of 0.25 (B = −1.37, Wald = 5.63, p = 0.02, 95% CI 0.08–0.79).

The significance of this result held even after controlling for other autonomic variables constant (blood pressure, PEP, and HF heart rate variability), although HF and PEP did show independent predictive relationship with myocardial infarction (see below). Similarly, CAR continued to significantly predict myocardial infarction after holding constant health behaviors, body mass index, health status, and cardiovascular medications.

HF Heart Rate Variability and PEP

Correlational analysis revealed the expected relations between myocardial infarction and sympathetic and parasympathetic control. Sympathetic cardiac control (as indexed by [−]PEP) was positively related to the prior incidence of a heart attack (r[226] = 0.19, p = 0.004), whereas parasympathetic cardiac control (as indexed by HF) was negatively associated with the prior occurrence of a heart attack (r[226] = −0.14, p = 0.04). Although higher sympathetic control may be a significant predictor of a prior myocardial infarction, the finding of a negative relation between CAR and myocardial infarction suggests that high sympathetic activity may be buffered by parasympathetic control.

In contrast to CAR, neither CAB nor the LF/HF ratio was a significant predictor of a prior myocardial infarction.

Path Analysis

Because spirituality is predictive of CAR and both spirituality and CAR are predictive of myocardial infarction, the potential role of CAR as a mediator of the relation between spirituality and myocardial infarction was evaluated by path analysis. As illustrated in Fig. 3, both spirituality and CAR were significantly predictive of the prior occurrence of myocardial infarction. As is apparent in the figure, however, the direct effect (c′) of spirituality was no longer significant after the effects of CAR were accounted for. This suggests that the pattern of autonomic control may be a mediator of the relation between spirituality and cardiac health.
https://static-content.springer.com/image/art%3A10.1007%2Fs12160-008-9027-x/MediaObjects/12160_2008_9027_Fig3_HTML.gif
Fig. 3

Path analysis of mediation. Spirituality (AS) was significantly predictive of both cardiac autonomic regulation (CAR) and prior myocardial infarction (MI). CAR was also predictive of MI and may be a mediator of the relationship between spirituality and infarction, as spirituality was no longer predictive of myocardial infarction (c′) after the effects of CAR were accounted for. Values in parenthesis are the coefficients

Discussion

The present study found that a measure of spirituality can predict important dimensions of autonomic regulation, in a middle-age and older population-based sample. Specifically, spirituality is associated with an increase in overall cardiac regulatory capacity (CAR) but not autonomic balance as indexed by CAB or the LF/HF ratio. The predictive relationship between spirituality and CAR held after demographics (age, gender, education, marital status, and income) and health behaviors (smoking, exercise, and physician visits) were accounted for. The underlying psychophysiological mediators between spirituality and patterns of autonomic regulation have yet to be determined, but the relation between spirituality and CAR was not simply related to a personality variable indexed by the Big3, nor was it attributable to other psychosocial characteristics including loneliness, perceived stress, social support, hostility, depression, or general satisfaction with others. Although church attendance has been widely studied in the literature on religiosity and health, this behavioral measure did not predict CAR in the present study. Rather, there appears to be something more specific to the perceived relationship with God. This is consistent with findings in the literature relating social factors with health-related outcomes and showing that relationship perceptions are more important than objective social realities in explaining their effects [87, 88]. Clearly, individuals attend religious services for a variety of reasons, so it is not surprising that the mental representation of one’s relationship with God is more proximal than religious behavior to health-related outcomes.

The relation between spirituality and CAR derived in part from a positive relationship between spirituality and parasympathetic control, as indexed by HF heart rate variability. It was also partially attributable to a positive relationship between spirituality and sympathetic cardiac control (as evidenced by PEP). Thus, spirituality is associated with enhanced cardiac regulation, regardless of its sympathetic or parasympathetic origin. Given sympathetic and parasympathetic control of the heart decreases with age, the present findings may indicate a protective effect of spirituality on the neuroregulatory control of the heart.

While high parasympathetic activity is generally considered to reflect a positive health state or reduced health risk [54, 60, 63, 72, 89], high sympathetic activity can be a clear health risk factor [4246]. High parasympathetic control, however, may serve to buffer the health consequences of sympathetic activity. This is in keeping with the observations that high overall heart rate variability including high LF heart rate variability (which includes a sympathetic contribution) is a predictor of positive outcome after myocardial infarction [54, 6062]. According to this view, high overall heart rate variability may index a high cardiac regulatory capacity (in both sympathetic and parasympathetic branches), which may have positive health benefits. In contrast, as noted above, low overall heart rate variability has been reported to be a risk factor for all cause mortality and morbidity [67, 68].

In this regard, the measure of cardiac regulatory capacity, CAR, was negatively associated with the prior incidence of myocardial infarction and that association continued after holding constant demographics, body mass index, and health behaviors (smoking, exercise, alcohol use, and physician visits). As expected, PEP (reflecting high sympathetic cardiac control) was a positive predictor of the prior occurrence of a myocardial infarction but accounted for less than half of the variance accounted for by CAR. The negative relationship between HF and myocardial infarction also likely contributed to the predictive power of CAR. However, CAR continued as a significant predictor of myocardial infarction even after HF and PEP were held constant in the regression analysis. This indicates that the CAR metric may reflect a physiological state that is more relevant to health than the independent sympathetic or parasympathetic controls or the autonomic balance between these controls as indexed by CAB (or LF/HF ratio). Because the highest values of CAR were associated with high sympathetic control (which predicts myocardial infarction), the associated high parasympathetic control may buffer the sympathetic risk factor.

In summary, spirituality was found to be associated with particular patterns of autonomic control and regulation. Specifically, spirituality predicts a high level of cardiac autonomic regulatory capacity, rather than a position along an autonomic balance continuum. This pattern of autonomic regulation may be a mediator of health effects of spirituality or religiosity, as high regulatory capacity was negatively associated with the prior occurrence of a myocardial infarction. Because this was a cross-sectional study, the causal relations between spirituality, CAR, and myocardial infarction have yet to be determined. As the Chicago Health, Aging, and Social Relations study continues, a longitudinal analysis may provide some insight as to whether spirituality antedates the autonomic patterns observed and whether the autonomic patterns antedate and predict the subsequent occurrence of an insult. Additional studies will also be necessary to identify the specific links between spirituality and the autonomic regulatory patterns—that is, how spirituality gets under the skin.

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© The Society of Behavioral Medicine 2008