Review

Oncology Reviews

, Volume 3, Issue 1, pp 3-18

An insight into tumoral hypoxia: the radiomarkers and clinical applications

  • Ana Margarida AbrantesAffiliated withBiophysics/Biomathematics Institute, IBILI, Faculty of Medicine, University of CoimbraFaculty of Medicine, Oncology, Genetics and Environment Research Center, CIMAGO
  • , Maria Elisa SerraAffiliated withChemistry Department, Faculty of Sciences and Technology, University of Coimbra
  • , Dina MurtinhoAffiliated withChemistry Department, Faculty of Sciences and Technology, University of Coimbra
  • , António Rocha GonsalvesAffiliated withChemistry Department, Faculty of Sciences and Technology, University of Coimbra
  • , Maria Filomena BotelhoAffiliated withBiophysics/Biomathematics Institute, IBILI, Faculty of Medicine, University of CoimbraFaculty of Medicine, Oncology, Genetics and Environment Research Center, CIMAGO Email author 

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Abstract

Tumoral hypoxia is related to severe structural abnormalities of tumor microvessels, leading to deteriorated O2 diffusion. This decreased O2 concentration in cancer cells compromises cellular functions, besides being responsible for resistance to radiation therapy. Consequently, it is very important to know the hypoxic status of a tumor. In this review, the different methodologies available for evaluating cellular hypoxia in vivo are discussed, particularly those in which the hypoxia information is obtained through imaging. Among these the nuclear medicine approach uses ligands to complex with radionuclides. The resulting radioactive complexes which may be single photon or positron emitters, are very useful as imaging probes. The nature of ligands and their corresponding complexes, with application or potential application as hypoxia detectors, will be described. A summary of the most significant results so far obtained in clinical or pre-clinical applications will also be discussed.

Keywords

Tumoral hypoxia Functional imaging Radiomarkers Nuclear medicine