Oncology Reviews

, Volume 2, Issue 4, pp 250–258

Historical perspective and advances in the treatment of multiple myeloma


DOI: 10.1007/s12156-008-0082-0

Cite this article as:
Harandi, A. & Laber, D.A. Oncol Rev (2008) 2: 250. doi:10.1007/s12156-008-0082-0


Corticosteroids and melphalan were used for decades to treat multiple myeloma. Combination chemotherapy has been extensively studied with similar overall survival rates to melphalan and prednisone. In the last decade, the development of new agents has progressed significantly. Thalidomide and its newer derivatives lenalidomide, bortezomib, and pegylated liposomal doxorubicin have drastically revolutionized treatment approaches. As a result, numerous clinical trials have yielded exciting treatment strategies resulting in therapeutic advances, and improved responses and overall survival of patients. This review summarizes the international uniform response criteria for multiple myeloma and gives a historical perspective on previous therapies with updates on the newest available treatments.


Multiple myelomaChemotherapyAdvances in treatment

Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  1. 1.Brown Cancer CenterUniversity of LouisvilleLouisvilleUSA