Oncology Reviews

, Volume 2, Issue 4, pp 203–213

MicroRNAs in the diagnosis, prognosis and treatment of cancer

Authors

  • Violaine Havelange
    • Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer CenterThe Ohio State University
    • Hematological section of the Human Genetic CenterUniversité Catholique de Louvain
  • Catherine E. A. Heaphy
    • Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer CenterThe Ohio State University
    • Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer CenterThe Ohio State University
Review

DOI: 10.1007/s12156-008-0076-y

Cite this article as:
Havelange, V., Heaphy, C.E.A. & Garzon, R. Oncol Rev (2008) 2: 203. doi:10.1007/s12156-008-0076-y

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate critical cell processes such as cell proliferation, apoptosis and differentiation by modulating gene expression. MiRNAs deregulation has been observed extensively in cancer. Elegant studies have demonstrated that miRNAs are involved in the initiation and progression of several malignancies. In this review we will address the role of miRNAs in the diagnosis and prognosis of cancer. The development of new drugs mimicking or blocking miRNAs will be discussed.

Keywords

MicroRNAsCancerMiRNAs profilingDiagnosisPrognosisTreatment

Copyright information

© Springer-Verlag Italia 2008