Oncology Reviews

, Volume 1, Issue 2, pp 91–102

Advances in diagnosis and treatment of malignant pleural mesothelioma


DOI: 10.1007/s12156-007-0011-7

Cite this article as:
Scagliotti, G.V. & Selvaggi, G. Oncol Rev (2007) 1: 91. doi:10.1007/s12156-007-0011-7


Malignant pleural mesothelioma (MPM) is an aggressive but relatively rare malignancy with median survival ranging from 8 to 14 months depending on stage and presentation of disease. New diagnostic procedures are urgently needed, selecting patients in earlier stages to evaluate therapeutic approaches which combine chemotherapy, surgery and radiotherapy. Combination chemotherapy represents the only resource available for advanced disease. The combination of cisplatin and pemetrexed is the treatment of choice. This review summarizes the latest developments in diagnostic techniques and the available therapeutic options for the management of MPM. Particular attention is given to the molecular basis of biologically targeted therapies to be used in the future.

Key words

Malignant Pleural Mesothelioma Prognostic Factors Mesothelin Osteopontin Chemotherapy Pemetrexed Targeted Therapy Vascular Endothelial Growth Factor Epidermal Growth Factor 

Copyright information

© Springer 2007

Authors and Affiliations

  • Giorgio Vittorio Scagliotti
    • 1
    • 2
  • Giovanni Selvaggi
    • 2
  1. 1.Department of Clinical & Biological Sciences, Thoracic Oncology Unit, San Luigi HospitalUniversity of TurinOrbassano (TO)Italy
  2. 2.Department of Clinical and Biological Sciences Thoracic Oncology UNIT, San Luigi HospitalUniversity of TurinOrbassano (Torino)Italy