Journal of Chemical Biology

, Volume 1, Issue 1, pp 63–77

Sterols and membrane dynamics

Review

DOI: 10.1007/s12154-008-0010-6

Cite this article as:
Dufourc, E.J. J Chem Biol (2008) 1: 63. doi:10.1007/s12154-008-0010-6

Abstract

The effect of sterols from mammals, plants, fungi, and bacteria on model and natural membrane dynamics are reviewed, in the frame of ordering–disordering properties of membranes. It is shown that all sterols share a common property: the ability to regulate dynamics in order to maintain membranes in a microfluid state where it can convey important biological processes. Depending on the sterol class, this property is modulated by molecular modifications that have occurred during evolution. The role of sterols in rafts, antibiotic complexes, and in protecting membranes from the destructive action of amphipathic toxins is also discussed.

Keywords

CholesterolAlpha-cholesterolCholesterol palmitateCholesterol sulphateCycloartenolSitosterolStigmasterolErgosterolBacteriohopanetetrolBacteriohopaneaminotriolModel and natural membranesMembrane raftsRegulating membrane dynamicsSolid-orderedLiquid-disorderedLiquid orderedSolid state NMR

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.UMR 5248 Chemistry and Biology of Membranes and Nanoobjects, CNRS–Université Bordeaux 1–ENITABCNRS Université BordeauxPessacFrance