Annals of Nuclear Medicine

, Volume 26, Issue 8, pp 616–621

Dual-time-point F-18 FDG PET/CT for evaluation in patients with malignant lymphoma

  • Takayoshi Shinya
  • Soichiro Fujii
  • Shoji Asakura
  • Toshitaka Taniguchi
  • Kotaro Yoshio
  • Aierken Alafate
  • Shuhei Sato
  • Tadashi Yoshino
  • Susumu Kanazawa
Original article

DOI: 10.1007/s12149-012-0619-y

Cite this article as:
Shinya, T., Fujii, S., Asakura, S. et al. Ann Nucl Med (2012) 26: 616. doi:10.1007/s12149-012-0619-y

Abstract

Objective

The aim of this study was to evaluate the usefulness of F-18 fluorodeoxyglucose (FDG) dual-time-point (DTP) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for the initial staging in patients with malignant lymphoma.

Methods

Forty-three patients had DTP PET/CT, with 60-min and 2-h scan [n = 8, Hodgkin’s lymphoma (HL); n = 12, indolent non-Hodgkin lymphoma (NHL); n = 23, aggressive NHL].

Results

A total of 524 lesions were evaluated (406 lymph nodes and 118 extra-nodal lesions). The maximum standardized uptake value (SUVmax) on 2-h delayed scan (SUV2) was significantly higher than those on 1-h early scan (SUV1) for all groups (P < 0.0001 for HL; P < 0.0001 for indolent NHL; P < 0.0001 for aggressive NHL). Significant differences were detected between HL and indolent NHL, between indolent NHL and the aggressive NHL for both SUV1 and SUV2 (each P < 0.0001). No significant differences were detected between HL and aggressive NHL for both SUV1 and SUV2 (P = 0.6891 for SUV1; P = 0.8828 for SUV2); however, significant differences were detected for the retention index of SUVmax between these groups (P = 0.0238).

Conclusions

DTP F-18 FDG PET/CT with a semiquantitative technique may have the potential to provide the more accurate diagnoses for the staging of malignant lymphoma and the more important role in predicting the histological grades of malignancy compared with single-time-point F-18 FDG-PET scan.

Keywords

Malignant lymphomaF-18 FDGPET/CTDual-time-point (DTP)Delayed scan

Copyright information

© The Japanese Society of Nuclear Medicine 2012

Authors and Affiliations

  • Takayoshi Shinya
    • 1
  • Soichiro Fujii
    • 2
  • Shoji Asakura
    • 3
  • Toshitaka Taniguchi
    • 4
  • Kotaro Yoshio
    • 1
  • Aierken Alafate
    • 1
  • Shuhei Sato
    • 1
  • Tadashi Yoshino
    • 5
  • Susumu Kanazawa
    • 1
  1. 1.Department of RadiologyOkayama University Medical SchoolOkayamaJapan
  2. 2.Department of Internal MedicineJapanese Red Cross Okayama HospitalOkayamaJapan
  3. 3.Department of HematologyNational Hospital Organization, Okayama Medical CenterOkayamaJapan
  4. 4.Department of RadiologyOkayama Kyokuto HospitalOkayamaJapan
  5. 5.Department of PathologyOkayama University Medical SchoolOkayamaJapan