Annals of Nuclear Medicine

, Volume 25, Issue 10, pp 701–716

Impact of FDG-PET/CT in the management of lymphoma

  • Shingo Baba
  • Koichiro Abe
  • Takuro Isoda
  • Yasuhiro Maruoka
  • Masayuki Sasaki
  • Hiroshi Honda
Invited review article

DOI: 10.1007/s12149-011-0549-0

Cite this article as:
Baba, S., Abe, K., Isoda, T. et al. Ann Nucl Med (2011) 25: 701. doi:10.1007/s12149-011-0549-0

Abstract

Since the introduction of 67Gallium-citrate 30 years ago, nuclear medicine has played an important role in the evaluation of malignant lymphoma. During that time, several radiotracers were evaluated as potential alternatives for the diagnosis of lymphoma, but the introduction of 18F-fluorodeoxyglucose PET (FDG-PET) marked a major turning point. FDG-PET took over most of the role of gallium, and is now an essential tool in the diagnosis of lymphoma. FDG-PET is increasingly being used for assessment of the tumor staging prior to treatment, for evaluating the response to treatment, and for monitoring the early reactions to therapy to predict the final outcome. FDG-PET has been shown to have more accurate diagnostic capability than conventional CT and MRI for distinguishing the tumor necrosis and residual masses frequently seen after therapy in lymphoma patients without any clinical and biochemical manifestation. Malignant lymphoma is the first disease for which FDG-PET was adopted as a tool for response assessment in the international standard criteria. However, lymphoma does not always display a clear high uptake, and there are some pitfalls in assessing the response to therapy. This review will highlight the most important applications of FDG-PET in lymphoma, focusing on the advantages and pitfalls of this imaging, and past and ongoing efforts to standardize the use of FDG-PET, particularly in response to assessment and therapy monitoring.

Keywords

Malignant lymphomaResponse assessment of lymphomaFDG-PET/CT in lymphomaPretreatment staging of lymphomaTherapy monitoring of lymphoma

Copyright information

© The Japanese Society of Nuclear Medicine 2011

Authors and Affiliations

  • Shingo Baba
    • 1
  • Koichiro Abe
    • 1
  • Takuro Isoda
    • 1
  • Yasuhiro Maruoka
    • 1
  • Masayuki Sasaki
    • 2
  • Hiroshi Honda
    • 1
  1. 1.Department of Clinical Radiology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Health Sciences, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan