Annals of Nuclear Medicine

, Volume 25, Issue 9, pp 657–666

Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey

Authors

    • Division of Cancer ScreeningResearch Center for Cancer Prevention and Screening, National Cancer Center
    • Department of RadiologyYokohama City University Graduate School of Medicine
  • Ryogo Minamimoto
    • Division of Nuclear Medicine, Department of RadiologyNational Center for Global Health and Medicine
  • Michio Senda
    • Division of Molecular ImagingInstitute of Biomedical Research and Innovation
  • Kimiichi Uno
    • Nishidai Clinic
  • Seishi Jinnouchi
    • Atsuchi Memorial Institute of RadiologyAtsuchi Memorial Clinic PET Center
  • Hiroshi Fukuda
    • Department of Nuclear Medicine and Radiology, Institute of Development, Aging and CancerTohoku University
  • Takeshi Iinuma
    • National Institute of Radiological Sciences
  • Eriko Tsukamoto
    • Medical Cooperation Teishinkai Central CI Clinic
  • Takashi Terauchi
    • Division of Cancer ScreeningResearch Center for Cancer Prevention and Screening, National Cancer Center
  • Tsuyoshi Yoshida
    • Koga Hospital 21 PET Center
  • Shinya Oku
    • Center for Advanced Information Science and TechnologyThe University of Aizu
  • Sadahiko Nishizawa
    • Hamamatsu Medical Imaging CenterHamamatsu Medical Photonics Foundation
  • Kengo Ito
    • Center for Development of Advanced Medicine for DementiaNational Center for Geriatrics and Gerontology
  • Kazuhiro Oguchi
    • Positron Imaging CenterAizawa Hospital
  • Masami Kawamoto
    • Yuai ClinicDiagnostic Imaging Center, Radiology
  • Rumi Nakashima
    • Japanese Red Cross Kumamoto Health Care Center
  • Hiroshi Iwata
    • Nagoya Radiological Diagnosis Foundation
  • Tomio Inoue
    • Department of RadiologyYokohama City University Graduate School of Medicine
Original article

DOI: 10.1007/s12149-011-0511-1

Cite this article as:
Murano, T., Minamimoto, R., Senda, M. et al. Ann Nucl Med (2011) 25: 657. doi:10.1007/s12149-011-0511-1

Abstract

Objective

The aim of this study was to estimate radiation exposure and evaluate the risks and benefits of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in cancer screening.

Methods

A nationwide survey of FDG-PET cancer screening was conducted in 2006, and the results were analyzed with a common index, “extension/shortening of the average life expectancy.”

Results

The average estimated effective dose was 4.4 mSv (male 4.7 mSv; female 4.0 mSv) for dedicated PET and 13.5 mSv (male 14.2 mSv; female 12.8 mSv) for PET/computed tomography (CT). The risk–benefit break-even age from the viewpoint of radiation exposure was in the 40s for men and 30s for women for dedicated PET and in the 50s for men and 50s (variable injection dose) or 60s (constant injection dose) for women for PET/CT.

Conclusions

FDG-PET cancer screening is beneficial for examinees above the break-even ages. The risks and benefits should be explained to examinees because of the larger radiation used in cancer FDG-PET screening compared with other X-ray tests.

Keywords

Cancer screening Positron emission tomography Radiation exposure Risk Benefit

Copyright information

© The Japanese Society of Nuclear Medicine 2011