Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey
- Takeshi Murano,
- Ryogo Minamimoto,
- Michio Senda,
- Kimiichi Uno,
- Seishi Jinnouchi,
- Hiroshi Fukuda,
- Takeshi Iinuma,
- Eriko Tsukamoto,
- Takashi Terauchi,
- Tsuyoshi Yoshida,
- Shinya Oku,
- Sadahiko Nishizawa,
- Kengo Ito,
- Kazuhiro Oguchi,
- Masami Kawamoto,
- Rumi Nakashima,
- Hiroshi Iwata,
- Tomio Inoue
- … show all 18 hide
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The aim of this study was to estimate radiation exposure and evaluate the risks and benefits of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in cancer screening.
A nationwide survey of FDG-PET cancer screening was conducted in 2006, and the results were analyzed with a common index, “extension/shortening of the average life expectancy.”
The average estimated effective dose was 4.4 mSv (male 4.7 mSv; female 4.0 mSv) for dedicated PET and 13.5 mSv (male 14.2 mSv; female 12.8 mSv) for PET/computed tomography (CT). The risk–benefit break-even age from the viewpoint of radiation exposure was in the 40s for men and 30s for women for dedicated PET and in the 50s for men and 50s (variable injection dose) or 60s (constant injection dose) for women for PET/CT.
FDG-PET cancer screening is beneficial for examinees above the break-even ages. The risks and benefits should be explained to examinees because of the larger radiation used in cancer FDG-PET screening compared with other X-ray tests.
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Annals of Nuclear Medicine
Volume 25, Issue 9 , pp 657-666
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Cancer screening
- Positron emission tomography
- Radiation exposure
- Industry Sectors
- Takeshi Murano (1) (2)
- Ryogo Minamimoto (3)
- Michio Senda (4)
- Kimiichi Uno (5)
- Seishi Jinnouchi (6)
- Hiroshi Fukuda (7)
- Takeshi Iinuma (8)
- Eriko Tsukamoto (9)
- Takashi Terauchi (1)
- Tsuyoshi Yoshida (10)
- Shinya Oku (11)
- Sadahiko Nishizawa (12)
- Kengo Ito (13)
- Kazuhiro Oguchi (14)
- Masami Kawamoto (15)
- Rumi Nakashima (16)
- Hiroshi Iwata (17)
- Tomio Inoue (2)
- Author Affiliations
- 1. Division of Cancer Screening, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan
- 2. Department of Radiology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
- 3. Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan
- 4. Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Hyogo, Japan
- 5. Nishidai Clinic, Tokyo, Japan
- 6. Atsuchi Memorial Institute of Radiology, Atsuchi Memorial Clinic PET Center, Kagoshima, Japan
- 7. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan
- 8. National Institute of Radiological Sciences, Chiba, Japan
- 9. Medical Cooperation Teishinkai Central CI Clinic, Hokkaido, Japan
- 10. Koga Hospital 21 PET Center, Fukuoka, Japan
- 11. Center for Advanced Information Science and Technology, The University of Aizu, Fukushima, Japan
- 12. Hamamatsu Medical Imaging Center, Hamamatsu Medical Photonics Foundation, Shizuoka, Japan
- 13. Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi, Japan
- 14. Positron Imaging Center, Aizawa Hospital, Nagano, Japan
- 15. Yuai Clinic, Diagnostic Imaging Center, Radiology, Kanagawa, Japan
- 16. Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan
- 17. Nagoya Radiological Diagnosis Foundation, Aichi, Japan