Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey
- Takeshi Murano,
- Ryogo Minamimoto,
- Michio Senda,
- Kimiichi Uno,
- Seishi Jinnouchi,
- Hiroshi Fukuda,
- Takeshi Iinuma,
- Eriko Tsukamoto,
- Takashi Terauchi,
- Tsuyoshi Yoshida,
- Shinya Oku,
- Sadahiko Nishizawa,
- Kengo Ito,
- Kazuhiro Oguchi,
- Masami Kawamoto,
- Rumi Nakashima,
- Hiroshi Iwata,
- Tomio Inoue
- … show all 18 hide
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The aim of this study was to estimate radiation exposure and evaluate the risks and benefits of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in cancer screening.
A nationwide survey of FDG-PET cancer screening was conducted in 2006, and the results were analyzed with a common index, “extension/shortening of the average life expectancy.”
The average estimated effective dose was 4.4 mSv (male 4.7 mSv; female 4.0 mSv) for dedicated PET and 13.5 mSv (male 14.2 mSv; female 12.8 mSv) for PET/computed tomography (CT). The risk–benefit break-even age from the viewpoint of radiation exposure was in the 40s for men and 30s for women for dedicated PET and in the 50s for men and 50s (variable injection dose) or 60s (constant injection dose) for women for PET/CT.
FDG-PET cancer screening is beneficial for examinees above the break-even ages. The risks and benefits should be explained to examinees because of the larger radiation used in cancer FDG-PET screening compared with other X-ray tests.
- Iinuma T, Tateno Y, Hashizume T, Umegaki Y, Kitabatake T. Benefit-risk analysis for mass screening of stomach cancer in Japan. 1. Life-saving vs. loss of life. Nippon Igaku Houshasen Gakkai Zasshi. 1977;37:1109–21.
- Iinuma T, Tateno Y. Risk–benefit analysis for mass screening of breast cancer utilizing mammography as a screening test. Nippon Igaku Houshasen Gakkai Zasshi. 1989;49:1091–5.
- Iinuma T, Tateno Y. Benefit-risk analysis of mass screening for lung cancer. Nippon Igaku Houshasen Gakkai Zasshi. 1990;50:101–6.
- Murano T, Iinuma T, Tateno Y, Daisaki H, Tateishi U, Terauchi T, et al. Risk–benefit analysis of 18FDG-PET cancer screening. Nippon Houshasen Gijutsu Gakkai Zasshi. 2008;64:1151–6.
- Japanese Society of Nuclear Medicine. The guideline of FDG-PET cancer screening. Kaku Igaku. 2007;44:1–28.
- International Commission on Radiological Protection. Radiation dose to patients from radiopharmaceuticals, ICRP Publication 80, Addendum to ICRP 53, J Valentine. Oxford: Pergamon Press; 1998.
- Jones D, Shrimpton P. NRPB-SR250: Normalised organ doses for x-ray computed tomography calculated using monte carlo techniques. National Radiological Protection Board; 1993.
- ImPACT. CT patient dosimetry Excel spreadsheet (version 0.99v, 17 June 2004). http://www.impactscan.org/.
- International Commission on Radiological Protection. Referenceman: anatomical physiological and metabolic characteristics. ICRP Publication 23, J Valentine. Oxford: Pergamon Press; 1975.
- 1990 Recommendation of the International Commission on Radiological Protection (ICRP Publication 60). Ann Icrp, vol 21. Oxford: Pergamon; 1991. p. 1–201.
- The 20th Life Tables For Japan 2005. Statistics and Information Department Minister’s Secretariat Ministry of Health, 2007.
- Cancer Statistics in Japan 2007. The Editorial of the Cancer Statistics in Japan; 2007.
- Pierce D, Shimizu Y, Preston D, Vaeth M, Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, Part 1. Cancer. 1950–1990. Radiat Res. 1996;146:1–27. CrossRef
- Minamimoto R, Senda M, Uno K, Jinnouchi S, Iinuma T, Ito K, et al. Performance profile of FDG-PET and PET/CT for cancer screening on the basis of a Japanese Nationwide Survey. Ann Nucl Med. 2007;21:481–98. CrossRef
- Okamoto N, Saruki N, Mikami H, Yamashita K, Maruyama Y, Yano T, et al. 5-year survival rates for primary cancer sites at cancer-treatment-oriented hospitals in Japan. Asian Pacif J Cancer Prev. 2006;7:46–50.
- Saruki N. 16-2 Chiiki gan-senmon-shinryou-shisetsu no sofuto-men no seibi-kakusyuu ni kansuru kenkyuu. A 2006 report of Grant-in-Aid for Cancer Research from the Ministry of Health, Labor, and Welfare, Japan. 2006; p. 21–34.http://www.gunma-cc.jp/sarukihan/seizonritu/index.html/.
- Daisaki H, Suzuki K, Fukukita H, Fukushima H, Satou T, Shinohara H. Influence of count rate on image quality in three-dimensional PET acquisition. Nippon Houshasen Gijutsu Gakkai Zasshi. 2008;64(4):407–16.
- Terauchi T, Murano T, Daisaki H, Kanou D, Shoda H, Kakinuma R, et al. Evaluation of whole-body cancer screening using 18F-2-deoxy-fluoro-d-glucose positron emission tomography: a preliminary report. Ann Nucl Med. 2008;22(5):379–85. CrossRef
- Ide M. Cancer screening with FDG-PET. Q J Nucl Med Mol Imaging. 2006;50(1):23–7.
- Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey
Annals of Nuclear Medicine
Volume 25, Issue 9 , pp 657-666
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Cancer screening
- Positron emission tomography
- Radiation exposure
- Industry Sectors
- Takeshi Murano (1) (2)
- Ryogo Minamimoto (3)
- Michio Senda (4)
- Kimiichi Uno (5)
- Seishi Jinnouchi (6)
- Hiroshi Fukuda (7)
- Takeshi Iinuma (8)
- Eriko Tsukamoto (9)
- Takashi Terauchi (1)
- Tsuyoshi Yoshida (10)
- Shinya Oku (11)
- Sadahiko Nishizawa (12)
- Kengo Ito (13)
- Kazuhiro Oguchi (14)
- Masami Kawamoto (15)
- Rumi Nakashima (16)
- Hiroshi Iwata (17)
- Tomio Inoue (2)
- Author Affiliations
- 1. Division of Cancer Screening, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan
- 2. Department of Radiology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
- 3. Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan
- 4. Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Hyogo, Japan
- 5. Nishidai Clinic, Tokyo, Japan
- 6. Atsuchi Memorial Institute of Radiology, Atsuchi Memorial Clinic PET Center, Kagoshima, Japan
- 7. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan
- 8. National Institute of Radiological Sciences, Chiba, Japan
- 9. Medical Cooperation Teishinkai Central CI Clinic, Hokkaido, Japan
- 10. Koga Hospital 21 PET Center, Fukuoka, Japan
- 11. Center for Advanced Information Science and Technology, The University of Aizu, Fukushima, Japan
- 12. Hamamatsu Medical Imaging Center, Hamamatsu Medical Photonics Foundation, Shizuoka, Japan
- 13. Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi, Japan
- 14. Positron Imaging Center, Aizawa Hospital, Nagano, Japan
- 15. Yuai Clinic, Diagnostic Imaging Center, Radiology, Kanagawa, Japan
- 16. Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan
- 17. Nagoya Radiological Diagnosis Foundation, Aichi, Japan