Annals of Nuclear Medicine

, 25:520

99mTc-GSA SPECT analysis was clinically useful to evaluate the effect of interferon in a patient with interferon non-responsive chronic hepatitis C

  • Rika Ishii
  • Hitoshi Togashi
  • Akiko Iwaba
  • Chikako Sato
  • Hiroaki Haga
  • Mai Sanjo
  • Kazuo Okumoto
  • Yuko Nishise
  • Jun-itsu Ito
  • Hisayoshi Watanabe
  • Koji Saito
  • Akio Okada
  • Kazuei Takahashi
  • Takafumi Saito
  • Sumio Kawata
Case Report

DOI: 10.1007/s12149-011-0484-0

Cite this article as:
Ishii, R., Togashi, H., Iwaba, A. et al. Ann Nucl Med (2011) 25: 520. doi:10.1007/s12149-011-0484-0

Abstract

We describe a 62-year-old woman with advanced chronic hepatitis C who showed no response to low-dose long-term interferon-beta monotherapy (3 MU, three times a week). The interferon monotherapy was continued for 2 years and 9 months. Despite this lack of response to interferon, the patient’s clinical course was good and liver function assessed by 99mTc-galactosyl human serum albumin single photon emission computed tomography (99mTc-GSA SPECT) analysis improved significantly. Improvement of the data obtained by 99mTc-GSA SPECT analysis justified continuation of the treatment. 99mTc-GSA SPECT analysis was clinically useful to evaluate the effect of interferon in a patient with interferon non-responsive chronic hepatitis C, despite a lack of reduction of the ALT level and HCV-RNA titer.

Keywords

Chronic hepatitis CInterferon non-responder99mTc-GSA SPECT

Copyright information

© The Japanese Society of Nuclear Medicine 2011

Authors and Affiliations

  • Rika Ishii
    • 1
  • Hitoshi Togashi
    • 1
    • 2
  • Akiko Iwaba
    • 3
  • Chikako Sato
    • 1
  • Hiroaki Haga
    • 1
  • Mai Sanjo
    • 1
  • Kazuo Okumoto
    • 1
  • Yuko Nishise
    • 1
  • Jun-itsu Ito
    • 1
  • Hisayoshi Watanabe
    • 1
  • Koji Saito
    • 1
  • Akio Okada
    • 4
  • Kazuei Takahashi
    • 4
  • Takafumi Saito
    • 1
  • Sumio Kawata
    • 1
  1. 1.Department of GastroenterologyYamagata University Faculty of MedicineYamagataJapan
  2. 2.Yamagata University Health Administration CenterYamagataJapan
  3. 3.Department of Pathological DiagnosticsYamagata University Faculty of MedicineYamagataJapan
  4. 4.Department of RadiologyYamagata University Faculty of MedicineYamagataJapan