Recent developments and future prospects of SPECT myocardial perfusion imaging
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Myocardial perfusion SPECT imaging is the most commonly performed functional imaging for assessment of coronary artery disease. High diagnostic accuracy and incremental prognostic value are the major benefits while suboptimal spatial resolution and significant radiation exposure are the main limitations. Its ability to detect hemodynamic significance of lesions seen on multidetector CT angiogram (MDCTA) has paved the path for a successful marriage between anatomical and functional imaging modalities in the form of hybrid SPECT/MDCTA system. In recent years, there have been enormous efforts by industry and academia to develop new SPECT imaging systems with better sensitivity, resolution, compact design and new reconstruction algorithms with ability to improve image quality and resolution. Furthermore, expected arrival of Tc-99m-labeled deoxyglucose in next few years would further strengthen the role of SPECT in imaging hibernating myocardium. In view of these developments, it seems that SPECT would enjoy its pivotal role in spite of major threat to be replaced by fluorine-18-labeled positron emission tomography perfusion and glucose metabolism imaging agents.
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- Recent developments and future prospects of SPECT myocardial perfusion imaging
Annals of Nuclear Medicine
Volume 24, Issue 8 , pp 565-569
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Solid-state detector
- Iterative reconstruction
- Multi-pinhole collimator
- Tc-99m-labeled deoxyglucose
- Industry Sectors
- Author Affiliations
- 1. Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN), Karachi, Pakistan
- 2. Department of Radiology, The Aga Khan University Hospital (AKUH), Karachi, Pakistan
- 4. Karachi Institute of Heart Diseases (KIHD), Karachi, Pakistan
- 3. GE Healthcare, Medical Diagnostics, Little Chalfont, UK