Annals of Nuclear Medicine

, Volume 24, Issue 8, pp 565–569

Recent developments and future prospects of SPECT myocardial perfusion imaging

Review Article

DOI: 10.1007/s12149-010-0400-z

Cite this article as:
Zaman, M.U., Hashmi, I. & Fatima, N. Ann Nucl Med (2010) 24: 565. doi:10.1007/s12149-010-0400-z


Myocardial perfusion SPECT imaging is the most commonly performed functional imaging for assessment of coronary artery disease. High diagnostic accuracy and incremental prognostic value are the major benefits while suboptimal spatial resolution and significant radiation exposure are the main limitations. Its ability to detect hemodynamic significance of lesions seen on multidetector CT angiogram (MDCTA) has paved the path for a successful marriage between anatomical and functional imaging modalities in the form of hybrid SPECT/MDCTA system. In recent years, there have been enormous efforts by industry and academia to develop new SPECT imaging systems with better sensitivity, resolution, compact design and new reconstruction algorithms with ability to improve image quality and resolution. Furthermore, expected arrival of Tc-99m-labeled deoxyglucose in next few years would further strengthen the role of SPECT in imaging hibernating myocardium. In view of these developments, it seems that SPECT would enjoy its pivotal role in spite of major threat to be replaced by fluorine-18-labeled positron emission tomography perfusion and glucose metabolism imaging agents.


Solid-state detectorCZTIterative reconstructionMulti-pinhole collimatorTc-99m-labeled deoxyglucose

Copyright information

© The Japanese Society of Nuclear Medicine 2010

Authors and Affiliations

  • Maseeh Uz Zaman
    • 1
    • 2
    • 4
  • Ibrahim Hashmi
    • 3
  • Nosheen Fatima
    • 1
    • 4
  1. 1.Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN)KarachiPakistan
  2. 2.Department of RadiologyThe Aga Khan University Hospital (AKUH)KarachiPakistan
  3. 3.GE Healthcare, Medical DiagnosticsLittle ChalfontUK
  4. 4.Karachi Institute of Heart Diseases (KIHD)KarachiPakistan