Annals of Nuclear Medicine

, Volume 24, Issue 8, pp 579–584

18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry

  • Go Miyashita
  • Tetsuya Higuchi
  • Noboru Oriuchi
  • Yukiko Arisaka
  • Hirofumi Hanaoka
  • Hideyuki Tominaga
  • Satoshi Morita
  • Mitsuyuki Miyakubo
  • Tomohiro Ishikita
  • Yoshiki Nakasone
  • Akihide Negishi
  • Satoshi Yokoo
  • Keigo Endo
Original Article

DOI: 10.1007/s12149-010-0398-2

Cite this article as:
Miyashita, G., Higuchi, T., Oriuchi, N. et al. Ann Nucl Med (2010) 24: 579. doi:10.1007/s12149-010-0398-2
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Abstract

Objective

l-3-[18F]-fluoro-α-methyl tyrosine (FAMT) is transported into cancer cells by l-type amino acid transporter 1 (LAT1). The purpose of the present study is to correlate the uptake of FAMT and FDG with the cellular proliferative activity measured by the Ki-67 labeling index (Ki-67 LI) in oral squamous cell carcinoma (OSCC).

Methods

Twenty-five patients with OSCC were enrolled in this study. Both FAMT-PET and FDG-PET were performed within 4 weeks before surgery in all cases. The uptake of FAMT and FDG was compared by semiquantitative analysis with maximal standardized uptake values (SUVmax) of the primary tumors. Ki-67 LI of the tumors was analyzed by immunohistochemical staining and correlated with the clinicopathologic variables and the uptake of PET tracers.

Results

For primary tumor detection, FAMT-PET exhibited a sensitivity of 84%, whereas that of FDG-PET was 88%. In all visible lesions, mean FDG uptake determined by average SUVmax was 9.7 (range 4.2–15.9) and mean FAMT uptake was 3.5 (range 1.3–8.5). The SUVmax of FAMT tended to show a better correlation with Ki-67 LI (r = 0.878) than that of FDG (r = 0.643).

Conclusions

Uptake of FAMT correlated with cellular proliferation of OSCC. FAMT-PET may be a useful procedure to evaluate tumor proliferation of OSCC.

Keywords

l-3-[18F]fluoro-α-methyl tyrosine 18F-FDG Oral squamous cell carcinoma Ki-67 LAT1 

Copyright information

© The Japanese Society of Nuclear Medicine 2010

Authors and Affiliations

  • Go Miyashita
    • 1
  • Tetsuya Higuchi
    • 2
  • Noboru Oriuchi
    • 2
  • Yukiko Arisaka
    • 2
  • Hirofumi Hanaoka
    • 3
  • Hideyuki Tominaga
    • 4
  • Satoshi Morita
    • 5
  • Mitsuyuki Miyakubo
    • 1
  • Tomohiro Ishikita
    • 1
  • Yoshiki Nakasone
    • 1
  • Akihide Negishi
    • 1
  • Satoshi Yokoo
    • 1
  • Keigo Endo
    • 2
  1. 1.Department of Stomatology and Oral SurgeryGunma University Graduate School of MedicineMaebashiJapan
  2. 2.Department of Diagnostic Radiology and Nuclear MedicineGunma University Graduate School of MedicineMaebashiJapan
  3. 3.Department of Bioimaging Information AnalysisGunma University Graduate School of MedicineMaebashiJapan
  4. 4.Department of Molecular ImagingGunma University Graduate School of MedicineMaebashiJapan
  5. 5.Department of Clinical Statistics and EpidemiologyYokohama City University Medical CenterYokohamaJapan

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