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In Situ Melanoma of the Gingiva Associated with Dense Inflammation and Pigment Deposition: A Potential Diagnostic Pitfall in Evaluating Stromal Invasion

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Abstract

Melanoma is a highly aggressive neoplasm in which the neoplastic cells display melanocytic differentiation. Less than 1 % of all melanomas arise in the mucosal surfaces of the oral cavity, with purely in situ lesions being exceedingly rare tumors, but with a favorable prognosis compared with invasive lesions. We describe the clinical, histopathological and immunohistochemical findings in an uncommon case of in situ mucosal melanoma of the oral cavity with intense tumor-associated pigment deposition and inflammation complicating the morphological assessment of infiltrative areas.

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Authors and Affiliations

  1. School of Dentistry, Oral and Maxillofacial Pathology, University of São Paulo, São Paulo, Brazil

    Bruno Tavares Sedassari, Marina Helena Cury Gallottini, Suzana Cantanhede Orsini Machado de Sousa & Décio dos Santos Pinto Jr.

  2. School of Dentistry, Stomatology, Santa Cecília University, Rua Oswaldo Cruz, Santos, SP, CEP: 11045-907, Brazil

    Nelise Alexandre da Silva Lascane, André Luis Santana de Freitas & Mário Cláudio Mautoni

  3. School of Medicine, Dermatopathology, University of São Paulo, São Paulo, Brazil

    Mirian Nacagami Sotto

Authors
  1. Bruno Tavares Sedassari
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  2. Nelise Alexandre da Silva Lascane
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  3. André Luis Santana de Freitas
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  4. Mário Cláudio Mautoni
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  5. Mirian Nacagami Sotto
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  6. Marina Helena Cury Gallottini
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  7. Suzana Cantanhede Orsini Machado de Sousa
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  8. Décio dos Santos Pinto Jr.
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Corresponding author

Correspondence to Nelise Alexandre da Silva Lascane.

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Sedassari, B.T., Lascane, N.A.d., de Freitas, A.L.S. et al. In Situ Melanoma of the Gingiva Associated with Dense Inflammation and Pigment Deposition: A Potential Diagnostic Pitfall in Evaluating Stromal Invasion. Head and Neck Pathol 10, 547–551 (2016). https://doi.org/10.1007/s12105-016-0728-3

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  • DOI: https://doi.org/10.1007/s12105-016-0728-3

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