Head and Neck Pathology

, Volume 6, Supplement 1, pp 1-2

First online:

Introduction: Human Papillomavirus in Head and Neck Cancer: An Update for 2012 with a Focus on Controversial Topics

  • James S. LewisJr.Affiliated withDepartment of Pathology and Immunology, Washington University in St. LouisDepartment of Otolaryngology—Head and Neck Surgery, Washington University in St. Louis Email author 

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Human papillomavirus has emerged as a major pathogen, capable of causing cancer at many different sites. In the head and neck, human papillomavirus is associated with many squamous cell carcinomas and is particularly important in the oropharynx. This is a fast moving topic with many important epidemiological, biological, pathological, and clinical features that are often confusing and misunderstood. This article introduces a series of timely reviews and editorials on this important subject in head and neck oncology.


Human papillomavirus p16 immunohistochemistry Squamous cell carcinoma Oropharynx Survival Head and neck