Head and Neck Pathology

, Volume 5, Issue 3, pp 302–305

Localized Tongue Amyloidosis in a Patient with Neurofibromatosis Type II

  • Dimitrios Andreadis
  • Athanasios Poulopoulos
  • Petros Papadopoulos
  • Apostolos Epivatianos
Case Report

DOI: 10.1007/s12105-011-0251-5

Cite this article as:
Andreadis, D., Poulopoulos, A., Papadopoulos, P. et al. Head and Neck Pathol (2011) 5: 302. doi:10.1007/s12105-011-0251-5

Abstract

Background

Localized Amyloidosis (AL) may rarely involve oral mucosa. This is the first known reported case describing the development of tongue AL in a 30-year-old patient with Neurofibromatosis (NF) type-2.

Case

A female patient presented with a painless, well-circumscribed nodule of the tongue. Her medical history included NF type-2 with chromosome-22 abnormal karyotype (mosaicism), multiple intracranial and spinal meningiomas/schwannomas and unilateral blindness/deafness. The biopsy of the excised lesion of the tongue revealed subepithelial accumulation of an amorphous, nodular, fibrillar material positive for Congo red. Blood examination showed increased Thyroxine-T4 due to thyroid multinodular colloid goiter, but excluded any other hematological/immunological disorder or organ dysfunction. No recurrence was observed after a six-month follow-up.

Conclusion

This case highlights the possibility of oral manifestations as the only sign of AL and reveals the unexpected co-existence of AL and NF 2, for the first time.

Keywords

Oral amyloidosisNeurofibromatosis type II

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Dimitrios Andreadis
    • 1
  • Athanasios Poulopoulos
    • 1
  • Petros Papadopoulos
    • 1
  • Apostolos Epivatianos
    • 1
  1. 1.Department of Oral Medicine/Pathology, School of DentistryAristotle University of ThessalonikiThessalonikiGreece