Head and Neck Pathology

, Volume 4, Issue 3, pp 242–245

Nerve Sheath Myxoma (Neurothekeoma) of the Gingiva, A Case Report and Review of the Literature

  • Rima A. Safadi
  • John W. Hellstein
  • May M. Diab
  • Huda M. Hammad
Case Report

DOI: 10.1007/s12105-010-0183-5

Cite this article as:
Safadi, R.A., Hellstein, J.W., Diab, M.M. et al. Head and Neck Pathol (2010) 4: 242. doi:10.1007/s12105-010-0183-5

Abstract

Nerve sheath myxoma (NSM) is a benign peripheral nerve sheath tumor that rarely occurs in the oral cavity. Among the 23 reported intraoral cases, no lesion has previously been reported on the gingiva. In this report, we describe the first gingival case of oral neurothekeoma with histopathologic and immunohistochemical characteristics. The patient, a 32 year old female presented with a slowly growing gingival mass diagnosed clinically as an epulis. The lesion was surgically excised. Histopathologically, the lesion presented as a submucosal multinodular mass composed of spindle and stellate-shaped cells with a myxoid background. Immunohistochemically, the tumor cells were sporadically positive for S-100 and NSE and negative for GFAP, EMA, SMA, CD68 and HMB45. The immunoprofile of this lesion confirmed a Schwann cell origin. The lesion was followed up for 10 months with no reports of recurrence.

Keywords

Nerve sheath myxoma Neurothekeoma Gingiva Oral cavity Benign tumor 

Copyright information

© Humana 2010

Authors and Affiliations

  • Rima A. Safadi
    • 1
    • 2
  • John W. Hellstein
    • 3
  • May M. Diab
    • 2
  • Huda M. Hammad
    • 1
    • 2
  1. 1.Department of Oral Surgery and Medicine, Faculty of DentistryJordan University of Science and TechnologyIrbidJordan
  2. 2.King Abdullah University HospitalIrbidJordan
  3. 3.Oral Pathology, Radiology and Medicine Department, College of DentistryThe University of IowaIowa CityUSA

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