Head and Neck Pathology

, Volume 4, Issue 2, pp 169–173

Extraneural Sclerosing Perineurioma of the Buccal Mucosa: A Case Report and Clinicopathologic Review

  • Vikki L. Noonan
  • David J. Greene
  • Gilbert Brodsky
  • Sadru P. Kabani
Case Report

DOI: 10.1007/s12105-010-0175-5

Cite this article as:
Noonan, V.L., Greene, D.J., Brodsky, G. et al. Head and Neck Pathol (2010) 4: 169. doi:10.1007/s12105-010-0175-5

Abstract

The perineurioma is an infrequently encountered benign peripheral nerve sheath tumor composed of a clonal proliferation of perineurial cells. Rare cases of perineurioma have been reported in the oral cavity. An extraneural sclerosing perineurioma arising in the buccal mucosa of a 17-year-old male is presented. Histopathologically, the tumor is composed of a well circumscribed nodular proliferation of spindle cells arranged in a storiform growth pattern, in some areas subtly arranged around vascular channels. The tumor cells reveal positive immunostaining for epithelial membrane antigen (EMA), collagen type IV and vimentin, and negative immunostaining for S-100 protein, consistent with a perineurial origin. To the best of our knowledge, this case represents the first report of an extraneural sclerosing perineurioma involving the oral cavity.

Keywords

Extraneural perineuriomaSclerosing perineuriomaBenign peripheral nerve sheath tumor

Copyright information

© Humana 2010

Authors and Affiliations

  • Vikki L. Noonan
    • 1
  • David J. Greene
    • 2
  • Gilbert Brodsky
    • 1
  • Sadru P. Kabani
    • 1
  1. 1.Department of PathologyHarvard Vanguard Medical AssociatesBostonUSA
  2. 2.Oral and Maxillofacial SurgeryPrivate PracticeNashuaUSA