The Changing Face of Head and Neck Cancer in the 21st Century: The Impact of HPV on the Epidemiology and Pathology of Oral Cancer
- William H. Westra
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The longstanding notion that head and neck squamous cell carcinoma (HNSCC) is a uniform disease process is changing. Divergence in epidemiologic trends among HNSCCs arising in different anatomic subsites has introduced a view that HNSCC is a heterogeneous group. Analysis of molecular genetic changes discloses not just individual tumor differences, but also consistent large-scale differences that permit the recognition of important tumor subtypes. One recently recognized subtype is the human papillomavirus (HPV)-positive oropharyngeal carcinoma. HPV-positive oropharyngeal cancer now dominates the head and neck oncology landscape, and its escalating incidence is impacting on diagnostic, preventive and therapeutic practices.
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- The Changing Face of Head and Neck Cancer in the 21st Century: The Impact of HPV on the Epidemiology and Pathology of Oral Cancer
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Head and Neck Pathology
Volume 3, Issue 1 , pp 78-81
- Cover Date
- Print ISSN
- Online ISSN
- Humana Press Inc
- Additional Links
- Human papillomavirus
- Oral cancer
- Head and neck squamous cell carcinoma
- In situ hybridization
- Author Affiliations
- 1. Department of Pathology and Otolaryngology/Head & Neck Surgery, The Johns Hopkins Medical Institutions, The Weinberg Bldg, Room 2242, 401 N, Broadway, Baltimore, MD, 21231, USA