Head and Neck Pathology

, 2:316

Low-Grade Papillary Adenocarcinoma of the Palate: The Significance of Distinguishing it from Polymorphous Low-Grade Adenocarcinoma

  • Jacob B. Hunter
  • Richard V. Smith
  • Margaret Brandwein-Gensler
Case Report

DOI: 10.1007/s12105-008-0082-1

Cite this article as:
Hunter, J.B., Smith, R.V. & Brandwein-Gensler, M. Head and Neck Pathol (2008) 2: 316. doi:10.1007/s12105-008-0082-1

Abstract

Low-grade papillary adenocarcinoma (LGPA) represents a relatively rare histological variant of polymorphous low-grade adenocarcinoma (PLGA). There has been a debate as to whether LGPA is associated with greater aggressive potential compared to PLGA; this is further obfuscated by the fact that diagnostic criteria for LGPA have not been well-defined. We believe that this is the first report of a patient with LGPA who developed metastases to the femur and scalp. We review the published evidence for classifying LGPA as distinct from PLGA. The weight of published data does support the idea that LGPA is oncologically distinct from LGPA. However, as uniform diagnostic criteria are lacking, we suggest a cut-off value of 10% or greater papillary formation as being necessary to separate LGPA from PLGA.

Keywords

Low-grade papillary adenocarcinomaPolymorphous low-grade adenocarcinomaOral salivary gland tumor

Copyright information

© Humana 2008

Authors and Affiliations

  • Jacob B. Hunter
    • 1
  • Richard V. Smith
    • 1
  • Margaret Brandwein-Gensler
    • 1
  1. 1.Departments of Otorhinolaryngology-Head Neck Surgery, Pathology, Albert Einstein College of Medicine (JH)Montefiore Medical CenterBronxUSA