, Volume 1, Issue 1, pp 38-43
Date: 28 Nov 2007

Update on Sinonasal Adenocarcinoma: Classification and Advances in Immunophenotype and Molecular Genetic Make-Up

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Introduction

Adenocarcinomas of various types comprise 10% to 20% of all primary malignant neoplasms of the nasal cavity and paranasal sinuses [1].

Salivary Gland-Type Adenocarcinomas

Adenocarcinomas of salivary-gland type are uncommon constituting 5–10% of sinonasal adenocarcinomas. They are thought to originate from seromucus glands of the nasal cavity and paranasal sinuses as well as the surface epithelium. Histologically, these carcinomas are similar to those originating from major and minor salivary glands [2]. The most common type is adenoid cystic carcinoma (Fig. 1) usually occurring in the maxillary sinus and nasal cavity [3]. Long-term prognosis is poor and patients usually die due to local spread with no metastasis. Adenocarcinoma Not Otherwise Specified may exhibit many high-grade, poorly differentiated growth patterns, and should be considered as a diagnostic entity for many high-grade salivary gland-type adenocarcinomas of the sinonasal tract. These tumors have a poor prognos