Biomolecular NMR Assignments

, Volume 8, Issue 2, pp 279–281

1H, 13C, and 15N NMR assignments of a Drosophila Hedgehog autoprocessing domain

  • Jian Xie
  • Zhenming Du
  • Brian Callahan
  • Marlene Belfort
  • Chunyu Wang
Article

DOI: 10.1007/s12104-013-9500-8

Cite this article as:
Xie, J., Du, Z., Callahan, B. et al. Biomol NMR Assign (2014) 8: 279. doi:10.1007/s12104-013-9500-8

Abstract

The Hedgehog (Hh) signaling pathway plays important roles in embryonic growth and patterning in different organisms. Abnormal activity of the Hh signaling pathway has been associated to cancers, holoprosencephaly and autism spectrum disorders. The backbone and side chain resonance assignments of a Drosophila Hh autoprocessing domain have been determined based on triple-resonance experiments with the [13C, 15N]-labeled and [2H, 13C, 15N])-labeled proteins.

Keywords

Assignments Autoprocessing Drosophila Hedgehog NMR 

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Jian Xie
    • 1
  • Zhenming Du
    • 1
  • Brian Callahan
    • 2
  • Marlene Belfort
    • 3
  • Chunyu Wang
    • 1
  1. 1.Biochemistry and Biophysics Graduate Program, Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyUSA
  2. 2.Department of ChemistryState University of New York at BinghamtonBinghamtonUSA
  3. 3.Department of Biological SciencesUniversity at AlbanyAlbanyUSA

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