Biomolecular NMR Assignments

, Volume 6, Issue 1, pp 75–77

1H, 13C, 15N and 31P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation


DOI: 10.1007/s12104-011-9328-z

Cite this article as:
Duszczyk, M.M. & Sattler, M. Biomol NMR Assign (2012) 6: 75. doi:10.1007/s12104-011-9328-z


Initiation of X-chromosome inactivation in female mammals depends on the non-coding RNA Xist. We have solved the NMR structure of a 14-nucleotide hairpin with a novel AUCG tetraloop fold from a Xist A-repeat that is essential for silencing. The 1H, 13C, 15N and 31P chemical shift assignments are reported.


NMR assignmentNon-coding RNARNA hairpinRNA tetraloopXist RNA A-repeatsX-inactivation

Supplementary material

12104_2011_9328_MOESM1_ESM.pdf (277 kb)
Supplementary material 1 (PDF 277 kb)

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Institute of Structural BiologyHelmholtz Zentrum MünchenNeuherbergGermany
  2. 2.Biomolecular NMR and Center for Integrated Protein Science Munich at Department ChemieTechnische Universität MünchenGarchingGermany