Article

Biomolecular NMR Assignments

, Volume 1, Issue 1, pp 85-87

First online:

Backbone NMR assignment of the internal interaction site of ALP

  • Nanna AlhoAffiliated withDepartment of Chemistry, University of Oulu
  • , Tuula KlaavuniemiAffiliated withDepartment of Biochemistry, University of Oulu
  • , Jari YlänneAffiliated withDepartment of Biochemistry, University of OuluDepartment of Biological and Environmental Sciences, University of Jyväskylä
  • , Perttu PermiAffiliated withInstitute of Biotechnology, National Biological NMR centre, University of Helsinki
  • , Sampo MattilaAffiliated withDepartment of Chemistry, University of Oulu Email author 

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Abstract

Earlier reports have shown that ALP has an internal interaction site. We were able to stablize the structure of this unfolded part to a great extent by aspartic acid, which allowed the backbone assignment. No secondary structure of the polypeptide was observed.

Keywords

NMR ALP Aspartic acid iHNCA